Abstract
In this article we present a new methodology—Biochemical Systems Theory and Analysis—as an alternative to traditional parametric statistical procedures for investigating differences between risk groups in a population. We review the systems theory and how it can be used to represent a model of processes influencing renal hemodynamics and sodium (Na+) excretion. We also discuss the potential for new measures of the biology of common diseases that can emerge from a synergism between systems theory and population-based statistical approaches.
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This work was supported in part by grants from the Public Health Service, RO1-HL30428, R01-HL39107 and General Clinical Research Center Grant RR0585.
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Reilly, S.L., Sing, C.F., Savageau, M.A. et al. Analysis of systems influencing renal hemodynamics and sodium excretion. I. Biochemical systems theory. Integrative Physiological and Behavioral Science 29, 55–73 (1994). https://doi.org/10.1007/BF02691281
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DOI: https://doi.org/10.1007/BF02691281