Skip to main content
SpringerLink
Log in

Forebrain regulation of cardiac function spectral and dimensional analysis of RR and QT intervals

  • Papers
  • Published:
Integrative Physiological and Behavioral Science Aims and scope Submit manuscript

Conclusions

We conclude that the QT and RR intervals show independent responses to various types of stimuli. The spectral and dimension analyses of the RR and QT intervals show characteristic responses both to mental (stress interview) and physical (exercise) perturbations. Such analyses may probe the effects of the forebrain on the heart in such a way as to assess its potentially deleterious impact and thus to predict cardiac risk.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  • Appel, M.L., Berger, R.D., Saul, J.P., Smith, J.M., and Cohen, R.J. (1989). Beat to beat variability in cardiovascular variables: Noise or music?Journal of American College of Cardiology, 14: 1139–48.

    Article  Google Scholar 

  • Bard, P. (1960). Anatomical organization of the central nervous system in relation to control of the heart and blood vessels.Physiol. Rev. 40 (supp 14): 3–26.

    Google Scholar 

  • Boudoulas, H., Geleris, P., Lewis, R.P., and Leier, C.V. (1981). Effect of increased adrenergic activity on the relationship between electrical and mechanical systole.Circulation, 64: 28–33.

    Article  PubMed  Google Scholar 

  • Cannon, W.E. (1929).Bodily Changes in Pain, Hunger, Fear, and Rage. New York: D. Appleton.

    Google Scholar 

  • Davidowski, T.A. and Wolf, S. (1984). The QT interval during reflex cardiovascular adaptation.Circulation, 69: 22–25.

    Article  PubMed  Google Scholar 

  • Ebert, P.A., Vanderbeck, R.B., Allgood, R.J., and Sabiston, D.C., Jr. (1970). Effect of chronic cardiac denervation on arrhythmias after coronary artery ligation.Cardiovascular Research, 4: 141–147.

    Article  PubMed  Google Scholar 

  • Engel, G.L. (1962).Fainting. 2nd ed. Springfield, IL: Charles C. Thomas.

    Google Scholar 

  • Hall, R.E., Livingston, R.R., and Bloor, M.D. (1977). Orbital cortical influences on cardiovascular dynamics and myocardial structure in conscious monkeys.Journal of Neurosurgery, 46: 638–647.

    Article  Google Scholar 

  • Hilton, D.M. (1980). Inhibition of the baroreceptor reflex by the brainstem defense centre. In: Sleight P. (ed.),Arterial Baroreceptors of Hypertension. Oxford: Oxford University Press, 318–323.

    Google Scholar 

  • Huang, M.H., Ebey, J., and Wolf, S. (1989). Responses of the QT interval of the electrocardiogram during emotional stress.Psychosomatic Medicine, 51: 419–427.

    PubMed  Google Scholar 

  • Huang, M.H. and Wolf, S. (1991). Heart rate-QT interval relationship during postural change and exercise.Integrative Physiological and Behavioral Science, 26: 5–17.

    Article  PubMed  Google Scholar 

  • Kleiger, R.E., Miller, J.P., and Bigger, J.T. and the Multicenter Post-Infarction Research Group. (1987). Decreased heart rate variability and its association with increased mortality after acute myocardial infarction.American Journal of Cardiology, 59: 256–262.

    Article  PubMed  Google Scholar 

  • La Rovere, M.T., Specchia, G., Mortara, A., and Schwartz, P.J. 1988. Baroreflex sensitivity, clinical correlates and cardiovascular mortality among patients with a first myocardial infarction: A prospective study.Circulation, 78: 816–824.

    Article  PubMed  Google Scholar 

  • Lown, B., Verrier, R.L., and Corbalan, R. (1973). Psychologic stress and threshold for repetitive response.Science, 182: 834.

    Article  PubMed  Google Scholar 

  • Lown, B., Verrier, R.L., and Rabinowitz, S.H. (1977). Neural and psychologic mechanisms and the problems of sudden death.American Journal of Cardiology, 39: 390.

    Article  Google Scholar 

  • Lown, B., Temte, J.V., Reich, P., Gaughan, C., Regestein, Q., and Hai, H. (1976). Basis of recurring ventricular fibrillation in the absence of coronary heart disease and its management.New England Journal of Medicine, 294: 623–629.

    Article  PubMed  Google Scholar 

  • Malliani, A., Pagani, M., Lombardi, F., and Cerutti, S. (1991). Cardiovascular neural regulation explored in the frequency domain.Circulation, 84: 482–492.

    PubMed  Google Scholar 

  • Negoescu, R., Porges, S.W., Goddard, P., Richardson, D., and Carlton, B. (1992). Short term oscillations in systolic time intervals. Proc. 14th Int. Conf. IEEE-EMBS, Paris, France, 14: 506–507.

    Google Scholar 

  • Negoescu, R., Wolf, S., and Porges, S.W. (1993). Power in the spectrum of the QT interval: a refined clue to the force of vetricular contraction in man. Proc. 12th Southern Biomed. Eng. Conf., New Orleans, LA, 117–119.

  • Nolen, T.G. and Hoy, R.R. (1984). Initiation of behavior of single neurons, the role of behavioral context.Science, 226: 992.

    Article  PubMed  Google Scholar 

  • Pagani, M., Mazzuero, G., Ferrari, A., Liberati, D., Cerutti, S., Vaitl, D., Tavazzi, L., and Malliani, A. (1991). Sympathovagal interaction during mental stress.Circulation, 83: II43-II51.

    PubMed  Google Scholar 

  • Perini, R., Orizio, C., Baselli, G., Cerutti, S., and Veicsteinas, A. (1990). The influence of exercise intensity on the power spectrum of heart rate variability.European Journal of Applied Physiology, 61: 153–160.

    Article  Google Scholar 

  • Richter, C.R. (1957). On the phenomenon of sudden death in animals and man.Psychosomatic Medicine, 19: 191–198.

    PubMed  Google Scholar 

  • Rüegg, P.C. and Nüesch, E. (1987). The effect of a new inotropic agent, DPI 201–106, on systolic time intervals and the electrocardiogram in healthy subjects.Journal of Clinical Pharmacology, 24: 453–458.

    Google Scholar 

  • Rushmer, F.F. and Smith, O.A. (1959). Cardiac control.Physiological Review, 39: 41–68.

    Google Scholar 

  • Scherf, D. and Boyd, L.J. (1946).Clinical Electocardiography. Philadelphia: Lippincott.

    Google Scholar 

  • Schneider, R.A. and Costiloe, J.P. (1972). The application of spectral analysis to the study of respiratory arrhythmia and other variations in heart rate. In S. Wolf (Ed.),The Artery and the Process of Arteriosclerosis. New York: Plenum Press.

    Google Scholar 

  • Schwartz, P.J. and Wolf, S. (1978). QT interval prolongation as predictor of sudden death in patients with myocardial infarction.Circulation, 57(6): 1074–1077.

    PubMed  Google Scholar 

  • Schwartz, P.J. and Stone, H.L. (1980). Left stellectomy in the prevention of ventricular fibrillation caused by acute myocardial ischemia in conscious dogs with anterior myocardial infarction.Circulation, 62: 1256.

    PubMed  Google Scholar 

  • Skinner, J.E., Lie, J.T., and Entman, M.L. (1975). Modification of ventricular fibrillation latency following coronary artery occlusion in the conscious pig: The effects of psychological stress and beta-adrenergic blockade.Circulation, 51: 656–667.

    PubMed  Google Scholar 

  • Skinner, J.E. and Reed, J.C. (1981). Blockade of a frontocortical-Brainstem Pathway Prevents Ventricular Fibrillation of the Ischemic Heart in Pigs.American Journal of Physiology, 240: H156-H163.

    PubMed  Google Scholar 

  • Skinner, J.E., Pratt, G.MS., and Vybiral, T.A. (1993). A reduction in the correlation dimension of heart beat intervals precedes imminent ventricular fibrillation in human subjects.American Heart Journal, 125: 731–743.

    Article  PubMed  Google Scholar 

  • Skinner, J.E., Goldberger, A.L., Mayer-Kress, G. and Ideker, R.E. (1990). Chaos in the heart: Implications of clinical cardiology.Biotechnology, 8: 1018–1024.

    Article  Google Scholar 

  • Skinner, J.E., Carpeggiani, C., Landisman, C.E., and Fulton, K.W. (1991). Correlation dimension of heartbeat intervals is reduced in conscious pigs by myocardial ischemia.Circulation Research, 68: 966–976.

    PubMed  Google Scholar 

  • Wenckebach, K.F. and Winterberg, H. (1927).Die Unregelmassige Hertztatigkent. Leipzig: Engelmann.

    Google Scholar 

  • Wolf, S. (1968). The Jeremiah Metzger Lecture. Neural mechanisms in sudden cardiac death. Transactions American Clinical & Climatological Association, 79: 158–176.

    Google Scholar 

  • Wolf, S. and Wolff, H.G. (1943).Human Gastric Function: An Experimental Study of Man and His Stomach. New York: Oxford University Press.

    Google Scholar 

  • Wolf, S. (1972).The Artery and the Process of Arteriosclerosis: Measurement and Modification, pp. 217–218. New York: Plenum Press.

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Totts Gap Medical Research Laboratories, Bangor, Pennsylvania

    Radu Negoescu, James E. Skinner & Stewart Wolf

  2. Institute of Hygiene, Bucharest, Romania

    Radu Negoescu

Authors
  1. Radu Negoescu
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. James E. Skinner
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Stewart Wolf
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Negoescu, R., Skinner, J.E. & Wolf, S. Forebrain regulation of cardiac function spectral and dimensional analysis of RR and QT intervals. Integrative Physiological and Behavioral Science 28, 331–342 (1993). https://doi.org/10.1007/BF02690930

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF02690930

Keywords

Search

Navigation