Abstract
The borderline hypertensive rat (BHR) responds to environmental and dietary stressors with elevated blood pressure. The first two months of a high salt diet appear to be the time of greatest sensitivity to salt effects on the blood pressure of BHR. The current study was conducted to examine whether exposure to salt diets varying in duration for up to two months differentially affects baseline blood pressures (systolic, SBP, and diastolic, DBP) and blood pressure responses to novel acoustic stimuli in BHR and normotensive Wistar-Kyoto (WKY) rats. Male BHR and WKY were fed a control (1%) salt diet or a high (8%) salt diet for 1, 1.5, 2.5, or 8.5 weeks. SBP and DBP responses to an acoustic stimulus (85 dB, 3 kHz) were measured upon completion of the diets at 12 weeks of age. Ten acoustic trials (one stimulus/minute) were presented and blood pressure responses were recorded in 2-second blocks spanning the 10 seconds prior to and following stimulus presentation. BHR had higher resting SBP and DBP than WKY, and 8.5 weeks of 8 percent salt increased SBP markedly in BHR. SBP and DBP labilities in the initial trial were greater in BHR than WKY with high salt diet durations of 2.5 and 8.5 weeks producing greater lability in later trials. Few differences were noted in pressor responses, but BHR had more dramatic depressor responses than WKY in early trials, and BHR pressures had a more dramatic return to baseline. It appears that genetic history and salt diet can affect blood pressure lability and recovery in response to novel stimuli in genetically susceptible animals.
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Hensley, I.P., Lawler, J.E., Zheng, G. et al. Effects of a high salt diet on blood pressure responses to acoustic stimuli in borderline hypertensive rats (BHR). Integrative Physiological & Behavioral Science 36, 275–292 (2001). https://doi.org/10.1007/BF02688796
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DOI: https://doi.org/10.1007/BF02688796