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Pathomorphological characteristics of experimental toxemia induced by thermostableYersinia pseudotuberculosis toxin

  • Morphology and Pathomorphology
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Bulletin of Experimental Biology and Medicine Aims and scope

Abstract

Pathogenic properties of thermostable toxin responsible for pathogenicity ofYersinia pseudotuberculosis were experimentally studied. The toxin exerted a pronounced polyorgan cytopathogenic effect with predominating degenerative destructive changes and membranolytic effect on cell ultrastructure of parenchymatous organs. The toxin is believed to be directly involved in the development of typical pathomorphological picture of pseudotuberculosis, which confirms its pathogenetic role.

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References

  1. Yu. V. Vertiev,Zh. Microbiol., No. 4, 86–92 (1987).

    Google Scholar 

  2. Yu. V. Ezepchuk,Pathogenicity as Function of Biomolecules [in Russian], Moscow (1985).

  3. L. M. Isachkova, A. A. Zhavoronkov, and F. F. Antonenko,Pathology of Pseudotuberculosis [in Russian], Vladivostok (1994).

  4. E. P. Nedashkovskaya, N. F. Timchenko, A. L. Besednov, and Yu. V. Vertiev,Zh. Mikrobiol., No. 4, 5–9 (1995).

    Google Scholar 

  5. General Human Pathology, Eds. A. I. Strukovet al. [in Russian], Moscow (1982).

  6. A. Yu. Pashin,Improvement of Methods for Isolation and Identification of Y. pseudotuberculosis Exotoxin [in Russian], Abstract of Cand. Med. Sci. Dissertation, Saratov (1986).

  7. S. D. Raznik,Characteristics of Biological Effect of Yersinia pseudotuberculosis Thermostable Toxin [in Russian], Abstract of Cand. Med. Sci. Dissertation, Vladivostok (1999).

  8. N. F. Timchenko, L. M. Isachkova, E. A. Shchipacheva,et al., Zh. Mikrobiol., No. 5, 43–46 (1983).

    PubMed  Google Scholar 

  9. J. A. Brown, W. L. West, W. M. Banks, and J. D. Marshall,J. Infect. Dis.,119, No. 3, 229–236 (1969).

    PubMed  CAS  Google Scholar 

  10. M. Schar and E. Thal,Proc. Soc. Exp. Biol. Med.,88, No. 1, 39–42 (1955).

    PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. Institute of Epidemiology and Microbiology, Siberian Division, Russian Academy of Medical Sciences, Vladivostok

    L. M. Isachkova, N. F. Timchenko, E. P. Nedashkovskaya & S. D. Raznik

Authors
  1. L. M. Isachkova
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  2. N. F. Timchenko
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  3. E. P. Nedashkovskaya
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  4. S. D. Raznik
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Additional information

Translated fromByulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 130, No. 11, pp. 593–597, November, 2000

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Isachkova, L.M., Timchenko, N.F., Nedashkovskaya, E.P. et al. Pathomorphological characteristics of experimental toxemia induced by thermostableYersinia pseudotuberculosis toxin. Bull Exp Biol Med 130, 1123–1126 (2000). https://doi.org/10.1007/BF02688197

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  • DOI: https://doi.org/10.1007/BF02688197

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