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Antimutagenic activity of afobazole in various regimens of treatment

  • Pharmacology and Toxicology
  • Published:
Bulletin of Experimental Biology and Medicine Aims and scope

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Abstract

The influence of a new 2-mercaptobenzimidazole derivative afobazole on cytogenetic effects of dioxidine and cyclophosphamide was studied by counting chromosome aberrations in bone marrow cells of C57B1/6 mice. Afobazole (1–100 mg/kg perorally) exhibited antimutagenic activity determined by its antioxidant properties. This activity depended on the dose and treatment shedule.

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Authors and Affiliations

  1. Laboratory of Mutagenesis Pharmacology, Institute of Pharmacology, Russian Academy of Medical Sciences, Moscow

    A. K. Zhanataev, A. D. Durnev & S. B. Seredin

Authors
  1. A. K. Zhanataev
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  2. A. D. Durnev
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  3. S. B. Seredin
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Additional information

Translated fromByulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 130, No. 11, pp. 539–542, November, 2000

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Zhanataev, A.K., Durnev, A.D. & Seredin, S.B. Antimutagenic activity of afobazole in various regimens of treatment. Bull Exp Biol Med 130, 1077–1079 (2000). https://doi.org/10.1007/BF02688183

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  • DOI: https://doi.org/10.1007/BF02688183

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