Skip to main content

Advertisement

Log in

Count and phagocytic activity of leukocytes in rats with experimental depressive syndrome caused by systemic administration of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine

  • General Pathology and Pathophysiology
  • Published:
Bulletin of Experimental Biology and Medicine Aims and scope

Abstract

Leukocyte count decreased, relative content of neutrophils and monocytes increased, and their phagocytic activity was suppressed in rats with 1-methyl-4-phenyl-1,2,3,4-tetrahydropyridine-induced depressive syndrome at the stage of acute behavioral depression. The severity of behavioral depression inversely correlated with changes in the absolute neutrophil and monocyte counts.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

References

  1. T. V. Davydova, V. G. Fomina, N. A. Krupina,et al., Byull. Eksp. Biol. Med.,123, No. 3, 308–311 (1997).

    Article  CAS  Google Scholar 

  2. L. V. Devoino and R. Yu. Il’yuchenok,Neurotransmitter Systems in Psychoneuroimmunomodulation [in Russian], Novosibirsk (1993), pp. 10–39.

  3. N. A. Kornetov,Psychogenic Depressions: Clinics and Pathogenesis [in Russian], Tomsk (1993), pp. 153–186.

  4. N. A. Krupina, G. N. Kryzhanovskii, T. E. Iordanskaya,et al., Byull. Eksp. Biol. Med.,123, No. 2, 138–142 (1997).

    Article  CAS  Google Scholar 

  5. N. A. Krupina, I. N. Orlova, and G. N. KryzhanovskiiIbid.,120, No. 8, 160–164 (1995).

    CAS  Google Scholar 

  6. N. A. Krupina, I. N. Orlova, and G. N. Kryzhanovskii,Zh. Vyssh. Nervn. Deyat.,49, No. 5, 865–876 (1999).

    Google Scholar 

  7. G. N. Kryzhanovskii, N. A. Krupina, and V. G. Kucheryanu,Ibid.,45, No. 2, 377–387 (1995).

    CAS  Google Scholar 

  8. B. Birmaher, B. S. Rabin, M. R. Garcia,et al., J. Am. Acad. Child. Adolesc. Psychiatry,33, No. 5, 671–678 (1994).

    Article  PubMed  CAS  Google Scholar 

  9. C. I. Castilla, A. Castilla, and M. Gurpegui,J. Physiol. Biochem.,54, No. 4, 203–215 (1998).

    PubMed  Google Scholar 

  10. J. P. Kelly, A. S. Wrynn, and B. E. Leonard,Pharmacol. Ther.,74, No. 3, 299–316 (1997).

    Article  PubMed  CAS  Google Scholar 

  11. B. E. Leonard and C. Song,Pharmacol. Biochem. Behav.,54, No. 1, 299–303 (1996).

    Article  PubMed  CAS  Google Scholar 

  12. K. I. Natban, D. L. Musselman, A. F. Schatzberg,et al., The American Psychiatric Press Textbook of Psychopharmacology, Eds. A. F. Schatzberg and Ch. B. Nemeroff, Washington (1995), pp. 439–477.

  13. S. J. Schleifer, S. E. Keller, S. G. Siris,et al., Arch. Gen. Psychiat.,42, 129–133 (1985).

    PubMed  CAS  Google Scholar 

  14. A. Seidel, V. Arolt, M. Hunstiger,et al., Acta Psychiatr. Scand.,94, No. 3, 198–204 (1996).

    Article  PubMed  CAS  Google Scholar 

  15. C. Song, B. Earley, and B. E. Leonard,Eur. Neuropsychopharmacol.,6, No. 3, 157–162 (1996).

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to N. A. Krupina.

Additional information

Translated fromByulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 130, No. 11, pp. 501–505, November, 2000

Rights and permissions

Reprints and permissions

About this article

Cite this article

Krupina, N.A., Davydova, T.V., Fomina, V.G. et al. Count and phagocytic activity of leukocytes in rats with experimental depressive syndrome caused by systemic administration of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine. Bull Exp Biol Med 130, 1041–1044 (2000). https://doi.org/10.1007/BF02688173

Download citation

  • Received:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF02688173

Key Words

Navigation