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Use of molecular connectivity indices to predict LC retention of dansylamides in six different eluent systems

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Summary

Molecular connectivity indices (x) through the sixth order were calculated and compared with measured reversed-phase liquid chromatographic retention data of sixteen dansyl derivatives of amines (dansylamides). Retention measurements were performed in the capacity factor, k′, range 1–30 with organic solvent-water eluents using acetone, acetonitrile, ethanol, methanol, 1-propanol and 2-propanol. Mainly valence level indices were selected to describe retention. Indices of different order were selected in the different eluents, suggesting that there are differences in the retention mechanism in these eluents. Retention can be predicted with great accuracy by the molecular connectivity indices, as the high correlations between the calculated and observed retention indicate.

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References

  1. K. Jinno, K. Kawasaki, Chromatographia18, 44 (1984).

    Article  CAS  Google Scholar 

  2. P. Jandera, H. Colin, G. Guiochon, Anal. Chem.54, 435 (1982).

    Article  CAS  Google Scholar 

  3. K. Jinno, A. Ishigaki, J. HRC & CC5, 668 (1982).

    CAS  Google Scholar 

  4. S. P. Assenza, P. R. Brown, J. Chromatogr.282, 477 (1983).

    Article  CAS  Google Scholar 

  5. A. Bylina, L. Gluzinski, K. Lesniak, B. Radwanski, P. A. Penczek, Chromatographia17, 132 (1983).

    Article  CAS  Google Scholar 

  6. G. M. Iskander, J. Strombom, A. M. Satti, J. Liq. Chromatogr.5, 1481 (1982).

    Article  CAS  Google Scholar 

  7. P. Lehtonen, J. Chromatogr.267, 277 (1983).

    Article  CAS  Google Scholar 

  8. P. Lehtonen, J. Chromatogr.,314, 141 (1984).

    Article  CAS  Google Scholar 

  9. M. J. M. Wells, C. R. Clark, R. M. Patterson, J. Chromatogr. Sci.19, 573 (1981).

    CAS  Google Scholar 

  10. Gy. Szasz, O. Papp, J. Vamos, K. Hanko-Novak, L. B. Kier, J. Chromatogr.269, 91 (1983).

    Article  CAS  Google Scholar 

  11. L. B. Kier, L. H. Hall, J. Med. Chem.20, 1631 (1977).

    Article  CAS  Google Scholar 

  12. M. J. M. Wells, C. R. Clark, R. M. Patterson, J. Chromatogr.235, 61 (1982).

    Article  CAS  Google Scholar 

  13. M. J. M. Wells, C. R. Clark, J. Chromatogr.243, 263 (1982).

    Article  CAS  Google Scholar 

  14. R. J. Hurtbise, T. W. Allen, H. F. Silver, J. Chromatogr.235, 517 (1982).

    Article  Google Scholar 

  15. J. Bojarski, L. Ekiert, Chromatographia15, 172 (1982).

    Article  CAS  Google Scholar 

  16. N. Kaneda, M. Sato, K. Yagi, Anal. Biochem.127, 49 (1982).

    Article  CAS  Google Scholar 

  17. E. Soczewinski, J. Jusiak, Chromatographia15, 309 (1982).

    Article  CAS  Google Scholar 

  18. B. A. Davis, J. Chromatogr.151, 252 (1978).

    Article  CAS  Google Scholar 

  19. G. Schwedt, H. H. Bussemas, Z. Anal. Chem.283, 23 (1977).

    Article  CAS  Google Scholar 

  20. N. E. Newton, K. Ohno, M. M. Abdel-Monem, J. Chromatogr.124, 277 (1976).

    Article  CAS  Google Scholar 

  21. N. D. Brown, R. B. Sweet, J. A. Kintzios, H. D. Cox, B. P. Doctor, J. Chromatogr.164, 35 (1979).

    Article  CAS  Google Scholar 

  22. SAS Institute Inc. SAS User’s Guide: Statistics, 1982 Edition. Cary, NC: SAS Institute Inc., 1982, 584 pp.

    Google Scholar 

Download references

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  1. Research Laboratories of the Finnish State Alcohol Company, Alko Ltd., POB 350, SF-00101, Helsinki 10, Finland

    P. Lehtonen

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  1. P. Lehtonen
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Lehtonen, P. Use of molecular connectivity indices to predict LC retention of dansylamides in six different eluent systems. Chromatographia 19, 316–321 (1984). https://doi.org/10.1007/BF02687762

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  • DOI: https://doi.org/10.1007/BF02687762

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