Summary
Various polysaccharide derivatives, particularly cellulose derivatives, were synthesized and used as chiral stationary phases for optical resolution by HPLC after being adsorbed on macroporous silica gel. Cellulose triacetate (CTA-II), which was synthesized under homogeneous conditions, showed a chiral recognition ability for many racemates. Other cellulose derivatives such as cellulose tribenzoate (OB), cellulose-trisphenylcarbamate (OC), cellulose tribenzyl ether (OE), and cellulose tricinnamate (OK) also showed unique chiral recognition. Among other polysaccharide derivatives, curdlan triacetate was also exhibited an effective chiral recognition.
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Ichida, A., Shibata, T., Okamoto, I. et al. Resolution of enantiomers by HPLC on cellulose derivatives. Chromatographia 19, 280–284 (1984). https://doi.org/10.1007/BF02687754
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DOI: https://doi.org/10.1007/BF02687754