Summary
A derivatization procedure for the gas chromatographic analysis of bifunctional amines likeβ-adrenergic blocking drugs is described. The method consists of a two-step reaction with methyldichlorophosphine and sulfur in presence of triethylamine to form cyclic methylphosphonothioic derivatives. The properties of these compounds are discussed and the application of the method to the quantitation of ephedrine in human body fluids is presented.
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Jacob, K., Schnabl, G. & Vogt, W. Gas chromatographic analysis of bifunctional amines after derivatization with methyldichlorophosphine and sulfur. Chromatographia 19, 216–218 (1984). https://doi.org/10.1007/BF02687740
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DOI: https://doi.org/10.1007/BF02687740