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A preliminary study of the effects of chemotherapeutic agents in combination with Chinese herbal compounds as immunomodulators in mouse S180

  • Traditional Chinese Medicine In Oncology
  • Published:
Chinese Journal of Cancer Research

Abstract

The effect of the Chinese herbal compound (CHC) on solid sarcoma 180 (S180) in Swiss mice was studied either alone or in combination with 5-fluorouracil (5FU), cyclophosphamide (CYT) or mitomycin C (MMC). The preliminary results indicated that combination treatment seemed to possess better antitumor activity than chemotherapy alone. The treatment with CHC alone however had neither an obvious antitumor effect in tumor bearing mice nor toxicity in normal mice. These results show that CHC may stimulate organs of the immune system such as the spleen to be immunomodulators and enhance the antitumor activity of some chemotherapeutic agents.

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Authors and Affiliations

  1. Department of Medical Oncology, Cancer Hospital, Shanghai Medical University, China

    Lu Wanqin & Xu Jingfang

  2. Laboratory of Clinical Pharmacology, Cancer Institute, Shanghai Medical University, China

    Jin Xingquan & Sun Zengyi

Authors
  1. Jin Xingquan
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  2. Lu Wanqin
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  3. Xu Jingfang
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  4. Sun Zengyi
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Jin, X., Lu, W., Xu, J. et al. A preliminary study of the effects of chemotherapeutic agents in combination with Chinese herbal compounds as immunomodulators in mouse S180 . Chinese Journal of Cancer Research 1, 73–76 (1989). https://doi.org/10.1007/BF02684824

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  • DOI: https://doi.org/10.1007/BF02684824

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