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Central nervous system radiotherapy in acute leukemia

  • Clinical Observations
  • Published:
Chinese Journal of Cancer Research

Abstract

From Dec. 1976 through June 1986, 474 patients with acute leukemia were treated with central nervous system (CNS) irradiation for the purpose of preventing relapse of CNS leukemia. Of the whole series, whole cranial irradiation at a dosage of 24 Gy and 4–5 intrathecal instillations of methotrexate (MTX) were given in 149 patients, simple intrathecal instillation of MTX in 44 patients and high dose intravenous MTX in 5 patients; the CNS relapse rates were 4.0%, 20.5% and 40.0% respectively. It was proved by our experience that whole cranial irradiation plus intrathecal MTX is the best approach to prevention of CNS leukemia relapses.

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Authors and Affiliations

  1. Beijing Institute for Cancer Research, China

    Shen Wenjiang

  2. General Hospital of Beijing Railway, China

    Han Peng & Huang Suqin

  3. Beijing Children’s Hospital, China

    Yang Shiyuan, Hu Yamei, Zhu Meizhan & Sui Caiqin

Authors
  1. Shen Wenjiang
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  2. Han Peng
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  3. Huang Suqin
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  4. Yang Shiyuan
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  5. Hu Yamei
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  6. Zhu Meizhan
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  7. Sui Caiqin
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Shen, W., Han, P., Huang, S. et al. Central nervous system radiotherapy in acute leukemia. Chinese Journal of Cancer Research 1, 69–72 (1989). https://doi.org/10.1007/BF02684823

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  • DOI: https://doi.org/10.1007/BF02684823

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