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Experimental research on the anti-cancer immunomodulative effect of the polysocoharibe-peptide of coriolus versicolor

  • Basic Investigations
  • Published:
Chinese Journal of Cancer Research

Abstract

Polysocoharibe-peptide of Coriolus Versicolor (PSP) is a new anti-cancer immunomodulative drug. The present paper reports on the experimental research done with this drug. It was found that PSP had the ability to recover hemolysin HC50, to increase the weight of the thymus, and increase the alexin of serum C3 and the IgG content of tumor bearing mice. PSP also significantly raised the phagocytic activity of macrophages in normal mice. PSP had a significant inhibitory effect on P388 and S180 cells. At the concentration of 1 mg/ml, PSP inhibited the proliferating activity of some human tumor cell lines, such as SGC 7901, SPC, SLY and Mei. It had a direct toxic effect on SPC cells. PSP significantly inhibited the synthesis of nucleic acids of Ehrlich ascites carcinoma cells. In addition, PSP was antagonistic to the side effects of chemotherapy and radiotherapy.

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Authors and Affiliations

  1. Laboratory of Pathology, Cancer Institute, Shanghai Medical University, China

    Xu Liangzhong

  2. Mushroom Research Laboratory, Department of Biology, Shanghai Teachers’ University, China

    Yang Qingyao

  3. Department of Pharmacology, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, China

    Zhou Jinxu, Chen Ruiting & Li Xiaoyu

  4. Shanghai Institute of Traditional Chinese Medicine, China

    Hu Yujuan

  5. Shanghai Second Pharmaceutical Factory, China

    Wang Junmo

Authors
  1. Xu Liangzhong
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  2. Yang Qingyao
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  3. Zhou Jinxu
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  4. Chen Ruiting
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  5. Li Xiaoyu
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  6. Hu Yujuan
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  7. Wang Junmo
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Xu, L., Yang, Q., Zhou, J. et al. Experimental research on the anti-cancer immunomodulative effect of the polysocoharibe-peptide of coriolus versicolor. Chinese Journal of Cancer Research 1, 7–12 (1989). https://doi.org/10.1007/BF02684809

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  • DOI: https://doi.org/10.1007/BF02684809

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