Skip to main content
Log in

The role of oncogenes and onco-suppressor genes in carcinogenesis

  • Reviews
  • Published:
Chinese Journal of Cancer Research

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

References

  1. Anderson MLM, Spandidos DA. Onco-suppressor genes and their involvement in cancer. Anticancer Res 1988; 8:873–880.

    PubMed  CAS  Google Scholar 

  2. Huebner RM, Todaro GJ. Oncogenes of RNA tumor viruses as determinants of cancer. Proc Natl Acad Sci USA 1969; 64:1087–1094.

    Article  PubMed  CAS  Google Scholar 

  3. Spandidos DA, Anderson MLM. Oncogenes and onco-suppressor genes: their involvement in cancer. J Pathol 1989. (In press)

  4. Klein G. The approaching era of the tumor suppressor genes. Science 1987; 238:1539–1545.

    Article  PubMed  CAS  Google Scholar 

  5. Bishop JM. The molecular genetics of cancer. Science 1987; 235:305–311.

    Article  PubMed  CAS  Google Scholar 

  6. Spandidos DA, Siminovitch L. Transfer of anchorage independence by isolated metaphase chromosomes in hamster cells. Cell 1977; 12:675–682.

    Article  PubMed  CAS  Google Scholar 

  7. Spandidos DA, Siminovitch L. Transfer of the marker for the morphologically transformed phenotype by isolated metaphase chromosomes in hamster cells. Nature 1978; 271:259–261.

    Article  Google Scholar 

  8. Weinberg RA. The action of oncogenes in the cytoplasm and nucleus. Science 1985; 230:770–776.

    Article  PubMed  CAS  Google Scholar 

  9. Spandidos DA. Mechanisms of carcinogenesis: the role of oncogenes transcriptional enhancers and growth factors. Anticancer Res 1985; 5:485–498.

    PubMed  CAS  Google Scholar 

  10. Spandidos DA. Ras oncogenes in cell transformation. ISI Atlas of Science: Immunology 1988; 1:1–6.

    CAS  Google Scholar 

  11. Spandidos DA. A unified theory for the development of cancer. Bioscience Rep 1986; 6:691–708.

    Article  CAS  Google Scholar 

  12. Land JC, Spandidos DA. The structure and function of eukaryotic enhancer elements and their role in oncogenesis. Anticancer Res 1986; 6:437–450.

    Google Scholar 

  13. Haluska FG, et al. Oncogene activation by chromosome translocation in human malignancy. Ann Rev Genet 1987; 21:321–345.

    Article  PubMed  CAS  Google Scholar 

  14. Stam K, et al. Evidence that thephy gene encodes a 160,000-dalton phosphoprotein with associated kinase activity. J Mol Cell Biol 1987; 7:1955–1960.

    CAS  Google Scholar 

  15. Barbacid M.Ras genes. Ann Rev Biochem 1987; 56:779–827.

    Article  PubMed  CAS  Google Scholar 

  16. Bos JL, et al. Prevalence ofras gene mutations in human colorectal cancers. Nature 1987; 327:293–297.

    Article  PubMed  CAS  Google Scholar 

  17. Forrester K, et al. Detection of high incidence of K-ras oncogenes during human colon tumorigenesis. Nature 1987; 327:298–303.

    Article  PubMed  CAS  Google Scholar 

  18. Spandidos DA. Oncogene activation in malignant transformation: a study of H-ras in human breast cancer. Anticancer Res 1987; 7:991–996.

    PubMed  CAS  Google Scholar 

  19. Liu E, et al. Mutations of the kirsten-ras proto-oncogene in human preleukemia. Nature 1987; 300:186–188.

    Article  Google Scholar 

  20. Yokota J, et al. Alterations ofmyc, myb andras Ha proto-oncogenes in cancer are frequent and show clinical correlation. Science 1986; 231:261–265.

    Article  PubMed  CAS  Google Scholar 

  21. Brodeur GM, et al. Amplification of N-myc in untreated human neuroblastomas correlates with advanced disease stage. Science 1988; 224:1121–1124.

    Article  Google Scholar 

  22. Varley JM, et al. Alterations to either c-erbB-2 (neu) or c-myc proto-oncogenes in breast carcinomas correlate with poor short-term prognosis. Oncogene 1987; 1:423–430.

    PubMed  CAS  Google Scholar 

  23. Slamon DJ, et al. Human breast cancer: correlation of relapse and survival with amplification of the HER-zneu oncogene. Science 1987; 235:177–182.

    Article  PubMed  CAS  Google Scholar 

  24. Mechler BM, et al. Molecular cloning of lethal (2) giant larvae, a recessive oncogene of Drosophila melanogaster. EMBO J 1985; 4:1551–1557.

    PubMed  CAS  Google Scholar 

  25. Opper M, et al. Hereditary suppression of lethal (2) giant larvae malignant tumor development in Drosophila by gene transfer. Oncogene 1987; 1:91–96.

    PubMed  CAS  Google Scholar 

  26. Friend SH, et al. A human DNA segment with properties of the gene that predisposes to retinoblastoma and osteosarcoma. Nature 1986; 323:643–646.

    Article  PubMed  CAS  Google Scholar 

  27. Lee W H, et al. Human retinoblastoma susceptibility gene: cloning, identification and sequence. Science 1987; 235:1394–1399.

    Article  PubMed  CAS  Google Scholar 

  28. Fung YKT, et al. Structural evidence for the authenticity of the human retinoblastoma gene. Science 1987; 236:1657–1661.

    Article  PubMed  CAS  Google Scholar 

  29. Lee WL, et al. The retinobiastoma susceptibility gene encodes a nuclear phosphoprotein associated with DNA binding activity. Nature 1987; 329:642–645.

    Article  PubMed  CAS  Google Scholar 

  30. Whyte P, et al. Association between an oncogene and an anti-oncogene: the adenovirus ElA proteins bind to the retinoblastoma gene product. Nature 1988; 334:124–129.

    Article  PubMed  CAS  Google Scholar 

  31. Harris H. The analysis of malignancy by cell fusion: the position in 1988. Cancer Res 1988; 48:3302–3306.

    PubMed  CAS  Google Scholar 

  32. Noda M, et al. Flat revertants isolated from Kirsten sarcoma virus-transformed cells are resistant to the action of specific oncogenes. Proc Natl Acad Sci USA 1983; 80:5602–5606.

    Article  PubMed  CAS  Google Scholar 

  33. Norton JD, et al. Expression of Kirsten murine sarcoma virus in transformed non-producer and revertant NIH/3T3 cells. Evidence for cell-mediated resistance to a viral oncogene in phenotypic reversion. J Virol 1984; 50:439–444.

    PubMed  CAS  Google Scholar 

  34. Sachs L. The molecular control of blood cell development. Science 1987; 238:1374–1379.

    Article  PubMed  CAS  Google Scholar 

  35. Sporn MB, Roberts AB. Peptide growth factors are multifunctional. Nature 1988; 332:217–219.

    Article  PubMed  CAS  Google Scholar 

  36. Chung J, et al. Trans-acting elements modulate expression of the human c-myc gene in Burkitt lymphoma cells. Proc Natl Acad Sci USA 1986; 83:7918–7922.

    Article  PubMed  CAS  Google Scholar 

  37. Meilink F, et al. Removal of a 67 base pair sequence in the non-coding region of the proto-oncogenefos converts it to a transforming gene. Proc Natl Acad Sci USA 1985; 82:4987–4991.

    Article  Google Scholar 

  38. Spandidos DA, Pintzas A. Differential potency and transactivation of normal and mutant T24-human H-ras 1 gene promoters. FEBS Lett 1988; 232:269–274.

    Article  PubMed  CAS  Google Scholar 

  39. Stoker M. Reguation of growth and orientation in hamster cells transformed by polyoma virus. Virology 1964; 24:165–174.

    Article  PubMed  CAS  Google Scholar 

  40. Baker RF. DNA-mediated alteration of the reversion frequency of transformed NIH/3T3 cells. Proc Natl Acad Sci USA 1983; 80:1174–1178.

    Article  PubMed  CAS  Google Scholar 

  41. Padmanabhan R, et al. Inhibition of HeLa cell growth following transfection with genomic DNA from human embryo fibroblasts. In UCLA Symposia on Molecular and Cellular Biology. New Series Vol. 58 Growth Factors, Tumor Promoters and Cancer Genes. (eds) N.H. Colburn, H.L. Moses and E.J. Stanbridge. 1988; 369–376.

  42. Spandidos DA, Anderson MLM. A study of mechanisms of carcinogenesis by gene transfer of oncogenes into mammalian cells. Mutat Res 1987; 185:271–291.

    PubMed  CAS  Google Scholar 

  43. Gambari R, Spandidos DA. Chinese hamster lung cells transformed with the human Ha-ras 1 oncogene: 5 Azacytidine mediated induction of adipogenic conversion. Cell Biol Int Rep 1986; 10:173.

    Article  Google Scholar 

  44. Spandidos DA. The effect of exogenous humanras andmyc oncogenes in morphological differentiation of the rat pheochromocytoma PC12 cells. Int J Dev Neurosci In Press, 1989.

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Spandidos, D.A., Lang, J.A. The role of oncogenes and onco-suppressor genes in carcinogenesis. Chinese Journal of Cancer Research 1, 70–74 (1989). https://doi.org/10.1007/BF02683541

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF02683541

Keywords

Navigation