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The effect of the transfer of lak cells, combined with alloimmunization, on the pulmonary metastases of rat mammary carcinoma

  • Basic Investigations
  • Published:
Chinese Journal of Cancer Research

Abstract

Alloimmunization was combined with lymphokine activated killer (LAK) cells to assess its effect on mammary carcinoma in rats. The animals were injected with both irradiated allo-splenocytes and syngeneic LAK cells. Metastatic lung nodules were markedly reduced using combined therapy when compared with the transfer of LAK cells or alloimmunization alone. IL-2 activity in the serum of alloimmunized rats could be detected. This activity, maintained in vivo for one week, may be responsible for enhancing the antitumor effect of transferred LAK cells.

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References

  1. Grimm EA, et al. Lymphokine-activated killer cells phenomenon. J Exp Med 1982; 155:1823–1841.

    Article  PubMed  CAS  Google Scholar 

  2. Lattime EC, Stutman O. The generation of culture activated killer cells (AK) is interleukin-2-dependent and requires self-la recognition. Int J Cancer 1985; 35:535–542.

    Article  PubMed  CAS  Google Scholar 

  3. Ba Denian, et al. Antimetastatic activity of LAK cells to rat fibrosarcoma (WBT-2M) and rat mammary carcinoma (SST-2). Chin Med J 1987; 100:2–7.

    PubMed  CAS  Google Scholar 

  4. Lafreniere R, Rosenberg SA. Successful immunotherapy of murine experimental hepatic metastases with lymphokine-activated killer cells and recombinant interleukin 2. Can Res 1985; 45:3735–3741.

    CAS  Google Scholar 

  5. Donohue JH, et al. The systemic administration of purified interleukin 2 enhances: The ability of sensitized murine lymphocytes to cure a disseminated syngeneic lymphoma. J Immunol 1984; 132:2123–2128

    PubMed  CAS  Google Scholar 

  6. Mule JJ, et al. Adoptive immunotherapy of established pulmonary metastases with LAK cells and recombinant interleukin 2. Science 1984; 225:1487–1489.

    Article  PubMed  CAS  Google Scholar 

  7. Rosenberg SA. A progress report on the treatment of 157 patients with advanced cancer using LAK cells and IL-2 or high dose IL-2 alone. New Engl J Med 1987; 316:899.

    Google Scholar 

  8. Gillis S. Biochemical characterization of lymphocyte regulatory molecules 11. Purification of a class of rats and human lymphokines. J Immunol 1980; 124:1954–1962.

    PubMed  CAS  Google Scholar 

  9. Wofsy D. Deficient interleukin 2 activity in MRL-IMP and C57BL/6 mice bearing the 1pr gene. J Exp Med 1982; 154:1671–1680.

    Article  Google Scholar 

  10. Mule JJ, et al. Antitumor efficacy of lymphokine-activavted killer cells and recombinant interleukin 2 in vivo: Survival benefit and mechanism of tumor escape in mice undergoing immunotherapy. Cancer Res 1986; 46:676–683.

    PubMed  CAS  Google Scholar 

  11. Jacobs SK, et al. Interleukin-2 or autologous lymphokine-activated killer cell treatment of malignant glioma: Phase I trial. Cancer Res 1986; 46:2101–2104.

    PubMed  CAS  Google Scholar 

  12. Lotze MT, et al. In vivo administration of purified human interleukin 2 II. Half life, immunologic effects, and expansion of peripheral lymphoid cells in vivo with recombinant IL-2. J Immunol 1985; 135:2865–2874.

    PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. Laboratory of Immunology, Cancer Institute, Harbin Medical University, China

    Li Songzhi & Ba Denian

Authors
  1. Li Songzhi
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  2. Ba Denian
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Li, S., Ba, D. The effect of the transfer of lak cells, combined with alloimmunization, on the pulmonary metastases of rat mammary carcinoma. Chinese Journal of Cancer Research 1, 13–16 (1989). https://doi.org/10.1007/BF02683530

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  • DOI: https://doi.org/10.1007/BF02683530

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