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Antiamnesic effect of acyl-prolyl-containing dipeptide (GVS-111) in compression-induced damage to frontal cortex

  • General Pathology and Pathophysiology
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Bulletin of Experimental Biology and Medicine Aims and scope

Abstract

Antiamnestic effect of acyl-prolyl-containing dipeptide GVS-111 was demonstrated in rats with bilateral compression-induced damage to the frontal cortex. Both intraperitoneal and oral administration of the dipeptide improved retrieval of passive avoidance responses in rats with compression-induced cerebral ischemia compared to untreated controls.

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Authors and Affiliations

  1. Institute of General Pathology and Pathophysiology, Russian Academy of Medical Sciences, Moscow

    G. A. Romanova

  2. Institute of Pharmacology, Russian Academy of Medical Sciences, Moscow

    T. Kh. Mirzoev, T. A. Gudasheva & R. U. Ostrovskaya

  3. Brain Research Institute, Russian Academy of Medical Sciences, Moscow

    I. V. Barskov & I. V. Victorov

Authors
  1. G. A. Romanova
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  2. T. Kh. Mirzoev
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  3. I. V. Barskov
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  4. I. V. Victorov
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  5. T. A. Gudasheva
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  6. R. U. Ostrovskaya
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Corresponding author

Correspondence to G. A. Romanova.

Additional information

Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 130, No. 9, pp. 272–274, September, 2000

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Romanova, G.A., Mirzoev, T.K., Barskov, I.V. et al. Antiamnesic effect of acyl-prolyl-containing dipeptide (GVS-111) in compression-induced damage to frontal cortex. Bull Exp Biol Med 130, 846–848 (2000). https://doi.org/10.1007/BF02682249

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  • DOI: https://doi.org/10.1007/BF02682249

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