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Effect of vilon on biological age and lifespan in mice

  • Biogerontology
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Bulletin of Experimental Biology and Medicine Aims and scope

Abstract

Subcutaneous administration of vilon (Lys-Glu) to female CBA mice starting from the 6th month of life increased physical activity and endurance, decreased body temperature, prolonged the lifespan, and prevented the development of spontaneous neoplasms. Vilon had no effect on age-related changes of estrous function and free radical processes. Long-term administration of vilon caused no unfavourable effects on animal development. The obtained results show safety of chronic vilon administration and allow to use this preparation for geroprotection and prophylaxis of age pathology.

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Authors and Affiliations

  1. Institute of Bioregulation and Gerontology, North-West Division of the Russian Academy of Medical Science, St.-Petersburg

    V. K. Khavinson, V. V. Malinin & V. G. Morozov

  2. Department of Cancerogenesis and Oncogerontology, N. N. Petrov Institute of Oncology, St.-Petersburg

    V. N. Anisimov, N. Y. Zavarzina, M. A. Zabezhinskii, O. A. Zimina, I. G. Popovich & A. V. Shtylik

Authors
  1. V. K. Khavinson
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  2. V. N. Anisimov
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  3. N. Y. Zavarzina
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  4. M. A. Zabezhinskii
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  5. O. A. Zimina
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  6. I. G. Popovich
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  7. A. V. Shtylik
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  8. V. V. Malinin
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  9. V. G. Morozov
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Additional information

Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 130, No. 7, pp. 88–91, July, 2000

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Khavinson, V.K., Anisimov, V.N., Zavarzina, N.Y. et al. Effect of vilon on biological age and lifespan in mice. Bull Exp Biol Med 130, 687–690 (2000). https://doi.org/10.1007/BF02682106

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  • DOI: https://doi.org/10.1007/BF02682106

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