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Accumulation of exogenous histone in rat brain parenchyma

  • Biophysics and Biochemistry
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Bulletin of Experimental Biology and Medicine Aims and scope

Abstract

In vivo histoautoradiographic study of cerebral accumulation of exogenous histone after its intracarotid infusion to anesthetized rats with intact liver and animals with experimental cirrhosis showed that histone penetrates brain capillary endotheliocyte membranes and gets into the nervous tissue.

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References

  1. D. Al'-Sufi, O. A. Goryukhina, G. P. Dem'yanenko, and Yu. V. Bobryshev,Vestn. Leningr. Gos. Univ., Ser. 3, Is. 3, No. 17, 129–132 (1991).

    Google Scholar 

  2. D. Al'-Sufi,The Study of Brain Tissue Penetration with an Exogenous Histone as a Potential Protein Carrier for Drugs, Abstract of Cand Biol. Sci. Dissertation, St. Petersburg (1992).

  3. I. P. Ashmarin, S. M. Zhdan-Pushkina, V. N. Kokryakov,et al., Izv. Acad. Nauk. SSSR, Ser. Biol., No. 4, 502–508 (1972).

    CAS  Google Scholar 

  4. V. B. Matyushichev, O. A. Goryukhina, and N. N. Nemtsova,Vopr. Med. Khimii,41, No. 2, 8–11 (1995).

    CAS  Google Scholar 

  5. V. A. Mischenko, O. A. Goryukhina, and R. D. Ilyuk,Byull. Eksp. Biol. Med.,118, No. 7, 86–88 (1994).

    Google Scholar 

  6. V. A. Mischenko and O. A. Goryukhina,Zhurn. Nevropatol. Psikhiatr.,96, No. 4, 116–120 (1996).

    Google Scholar 

  7. L. A. Osterman,Investigation of Biological Macromolecules by Electrofocusing, Immunoelectrophoresis, and Radioisotope Techniques [in Russian], Moscow (1983), pp. 236–239.

  8. W. M. Pardridge, J. Eisenberg, and W. T. Cefalu,Am. J. Physiol.,249, No. 3, 264–267 (1985).

    Google Scholar 

  9. W. M. Pardridge, D. M. Nowlin, J. Calaycay, and J. E. Shively,J. Neurochem.,53 No. 4, 1014–1018 (1989).

    Article  PubMed  CAS  Google Scholar 

  10. W. M. Pardridge, D. Triguero, and J. Buciak,Pharmacol. Exp. Ther.,251, No. 3, 821–826 (1989).

    CAS  Google Scholar 

  11. W. M. Pardridge,J. Cereb. Blood Flow. Metab.,17, No. 7, 7113–731 (1997).

    Google Scholar 

  12. W. Ch. Shen, H. J.-P. Ryser,Proc. Natl. Acad. Sci. USA,75, No. 4, 1872–1876 (1978).

    Article  PubMed  CAS  Google Scholar 

  13. L. J. Strausbaugh,Brain Res.,409, No. 2, 221–226 (1987).

    Article  PubMed  CAS  Google Scholar 

  14. D. Triguero, J. B. Buciak, J. Yang, and W. M. Pardridge,Proc. Natl. Acad. Sci. USA,86, No. 12, 4761–1765 (1989).

    Article  PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. Department of Biochemistry, A. A. Ukhtomsky Institute of Physiology, St. Petersburg State University, St. Petersburg

    O. A. Gorukhina, R. D. Ilyuk & I. V. Mishchenko

  2. Department of Nervous Diseases with Course of Neurosurgery, I. I. Mechnikov State Medical Academy, St. Petersburg

    O. A. Gorukhina, R. D. Ilyuk & I. V. Mishchenko

Authors
  1. O. A. Gorukhina
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  2. R. D. Ilyuk
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  3. I. V. Mishchenko
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Corresponding author

Correspondence to R. D. Ilyuk.

Additional information

Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 130, No. 7, pp. 63–66, July, 2000

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Gorukhina, O.A., Ilyuk, R.D. & Mishchenko, I.V. Accumulation of exogenous histone in rat brain parenchyma. Bull Exp Biol Med 130, 665–668 (2000). https://doi.org/10.1007/BF02682100

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  • DOI: https://doi.org/10.1007/BF02682100

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