Abstract
The efficiency of ascorbate and α-tocopherol as stabilizers of β-carotene, which is widely used in complex therapy and prevention of some diseases accompanied by oxidative stress, was studied. The latency of induced β-carotene oxidation linearly depends on ascorbate concentration, while steady-state rate nonlinearly depends on the concentration of α-tocopherol, which attests to involvement of antioxidants in various stages of chain oxidation of β-carotene.
Similar content being viewed by others
References
E. V. Alekseev, A. B. Gagarina, N. M. Evteeva,et al., Izv. Akad. Nauk, Ser. Khim., No. 11, 2474–2480 (1968).
E. V. Alekseev, A. B. Gagarina, L. A. Vakulova,et al., ——Ibid., No. 2, 312–316 (1972).
S. B. Gomboeva, N. N. Gessler, K. B. Shumaev,et al., Biokhimiya,63, No. 2, 224–229 (1998).
A. B. Kapitanov and A. M. Pimenov,Usp. Sovr. Biol.,116, No. 2, 179–193 (1996).
O. T. Kasaikina, Z. S. Kartasheva, T. V. Lobanova, and T. V. Sirota,Biol. Membr.,15, No. 2, 168–175 (1998).
N. M. Emanuel' and D. G. Knorre,Textbook on Chemical Kinetics [in Russian], Moscow (1974), p. 314.
B. N. Ames, M. K. Shigenaga, and T. M. Hagen,Proc. Natl. Acad. Sci. USA,90, No. 17, 7915–7922 (1993).
G. W. Burton and K. U. Ingold,Science,224, 569–575 (1984).
G. W. Burton and K. U. Ingold,Acc. Chem. Res.,19, 194–201 (1986).
D. Horn,Angew. Macromol. Chem.,166–167, 139–153 (1989).
N. I. Krinsky, in:Free Radicals Oxidative Stress and Antioxidants, New York (1998), pp. 323–332.
D. C. Liebler, in: Ed. L. M. Canfield,Carotenoids in Human Health Antioxidant Reactions of Carotenoids, New York (1993), pp. 20–31.
A. Mortensen and L. H. Skibsted,FEBS Lett.,417, No. 3, 261–266 (1997).
V. A. Tyurin, G. Garta, Y. Y. Tyurina,et al., Lipids,32, No. 2, 131–142 (1997).
X. D. Wang and N. I. Krinsky, in: Ed. P. I. Quinn,Subcellular Biochemistry: Fat Soluble Vitamins, Vol. 30, London (1998), pp. 159–180.
Author information
Authors and Affiliations
Corresponding author
Additional information
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 130, No. 7, pp. 59–62, July, 2000
Rights and permissions
About this article
Cite this article
Kozachenko, A.I., Gurevich, S.M. & Nagler, L.G. Effect of ascorbate and α-tocopherol on resistance of β-carotene to oxidation. Bull Exp Biol Med 130, 661–664 (2000). https://doi.org/10.1007/BF02682099
Received:
Issue Date:
DOI: https://doi.org/10.1007/BF02682099