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Effects of Angiotensin II and proliferative activity of epitheliocytes and smooth muscle cells of the tracheobronchial system in newborn albino rats

  • General Pathology and Pathological Physiology
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Abstract

Angiotensin II was injected intraperitoneally in a dose of 5×10−8 mol/kg to newborn rats from then 2nd to 6th day of life. Autoradiography with3H-thymidine showed that angiotensin II stimulated DNA synthesis in epitheliocytes and smooth muscle cells of the trachea and large (cartilaginous) and small (noncartilaginous) bronchi, intensified lipid peroxidation, and activated the antioxidant defense system in the lungs.

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Lebed’ko, O.A., Timoshin, S.S. & Bespalova, N.N. Effects of Angiotensin II and proliferative activity of epitheliocytes and smooth muscle cells of the tracheobronchial system in newborn albino rats. Bull Exp Biol Med 130, 636–638 (2000). https://doi.org/10.1007/BF02682091

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  • DOI: https://doi.org/10.1007/BF02682091

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