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Cerivastatin modulates antiatherogenic properties of high-density lipoproteins in patients with coronary heart disease and hyperlipidemia

  • Experimental Methods for Clinical Practice
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Abstract

The effects of cerivastatin on antiatherogenic properties of high-density lipoproteins were studied in patients with coronary heart disease and hyperlipidemia. Apart from hypolipidemic effects, cerivastatin changed the phospholipid composition of high-density lipoproteins and improved their cholesterol-acceptor properties. This effect was most pronounced in the serum from patients with low content of high-density lipoprotein cholesterol. These data indicate that cerivastatin modulates antiatherogenic properties of high-density lipoproteins.

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Authors and Affiliations

  1. Department of Metabolic Disorders, Research Center of Preventive Medicine, Russian Ministry of Health, Moscow

    I. N. Ozerova, D. M. Jeevan, A. P. Serdyuk, I. V. Paramonova, N. M. Akhmedzhanov, V. A. Metel’skaya & N. V. Perova

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  1. I. N. Ozerova
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  2. D. M. Jeevan
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  3. A. P. Serdyuk
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  4. I. V. Paramonova
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  5. N. M. Akhmedzhanov
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  6. V. A. Metel’skaya
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  7. N. V. Perova
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Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 130, No. 10, pp. 433–436, October, 2000

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Ozerova, I.N., Jeevan, D.M., Serdyuk, A.P. et al. Cerivastatin modulates antiatherogenic properties of high-density lipoproteins in patients with coronary heart disease and hyperlipidemia. Bull Exp Biol Med 130, 983–985 (2000). https://doi.org/10.1007/BF02682045

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  • DOI: https://doi.org/10.1007/BF02682045

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