Abstract
In vitro experiments showed that P2X-receptor agonist α,β-methylene-ATP and electrical field stimulation in the presence of muscarinic and α-adrenoreceptors blockers induced contractile responses of isolated guinea pig bladder, which were more pronounced at 30°C than at 37°C or 42°C. P2x-receptor antagonist pyridoxal-6-phosphate-2′,4′-disulfonic acid, produced a more potent inhibitory effect on contractions induced by electrical field stimulation at 30°C in comparison with that at 37°C or 42°C while the contractions induced by α,β-methylene-ATP were similarly suppressed at all examined temperatures.
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Translated fromByulleten’s Eksperimental’noi Biologii i Meditsiny, Vol. 130, No. 10, pp. 407–410, October, 2000
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Ziganshin, A.U., Rychkov, A.V. & Ziganshina, L.E. Effect of temperature on guinea pig urinary bladder contraction mediated via P2X-receptors. Bull Exp Biol Med 130, 961–963 (2000). https://doi.org/10.1007/BF02682038
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DOI: https://doi.org/10.1007/BF02682038