Abstract
We studied ultrastructure of nuclear compartment in cardiomyocytes during regenerative and plastic insufficiency of the myocardium induced by anthracycline antibiotic daunomycin. A peculiarity of ultrastructural organization of cardiomyocyte nuclei under these conditions is almost complete disappearance of the heterochromatin lumps. The earliest changes in nucleoli under conditions of disturbed DNA-dependent RNA synthesis are segregation of the granular and fibrillar nucleolonema components. Deep alterations in the nucleoli manifested by fragmentation and annulation correlate with pronounced changes in cardiomyocytes ultrastructure, intensive lysis of the myofilaments, reduction of the organelles, and enhanced autophagocytosis.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
A. P. Avtsyn and V. A. Shakhlamov,Ultrastructural Principles of Cellular Pathology [in Russian], Moscow (1979).
G. I. Nepomnyashchikh, L. M. Nepomnyashchikh, and Yu. G. Tsellarius,Regeneration and Plastic Insufficiency of Organs during General Chronic Pathological Processes [in Russian], Novosibirsk (1992).
L. M. Nepomnyashchikh,Alternating Insufficiency of Cardiac Muscle Cells [in Russian], Moscow (1998).
L. M. Nepomnyashchikh,Regeneration and Plastic Insufficiency of Cardiac Muscle Cells [in Russian], Moscow (1998).
L. A. Semenova, L. M. Nepomnyashchikh, and D. E. Semenov,Morphology of Plastic Insufficiency of Cardiac Muscle Cells [in Russian], Novosibirsk (1985).
R. Jeyaseelan, C. Poizat, H.-T. Wu, and L. Kedes,J. Biol. Chem.,272, 5828–5832 (1997).
R. Jeyaseelan, C. Poizat, R. K. Baker,et al.,Ibid., J. Biol. Chem.,272, 22,800–22,808.
Y. J. Kang, Z.-X. Zhou, G.-W. Wang,et al., Ibid.,,275, 13,690–13,698 (2000).
M. Kurabayashi, R. Jeyaseelan, and L. Kedes,Ibid.,,269, 6031–6039 (1994).
J. A. Merski, Y. Daskal, and H. Busch,Cancer Res.,36, 1580–1584 (1976).
D. B. Sawyer, R. Fukazawa, M. A. Arstall, and R. A. Kelly,Circ. Res.,84, 257–265 (1999).
H. Shinozuka, L. W. Estes, and E. Farber,Am. J. Pathol.,64, 241–256 (1971).
R. Simard and W. Bernhard,Int. J. Cancer,1, 463–479 (1966).
R. Simard and W. Bernhard,J. Cell. Biol.,34, 61–76 (1967).
W. Zhu, Y. Zou, R. Aikawa,et al., Circulation,100, 2100–2107 (1999).
Author information
Authors and Affiliations
Corresponding author
Additional information
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 130, No. 12, pp. 681–687, December, 2000
Rights and permissions
About this article
Cite this article
Nepomnyashchikh, L.M., Lushnikova, E.L. & Semenov, D.E. Ultrastructure of nuclear compartment in cardiomyocytes during regenerative and plastic insufficiency of the myocardium. Bull Exp Biol Med 130, 1196–1201 (2000). https://doi.org/10.1007/BF02682024
Received:
Issue Date:
DOI: https://doi.org/10.1007/BF02682024