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Hemodynamic effects of tetrindol in alert normotensive mice and rats after blockade of nitric oxide synthesis

  • Pharmacology and Toxicology
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Bulletin of Experimental Biology and Medicine Aims and scope

Abstract

Single intravenous injection of antidepressant tetrindol (1 and 10 mg/kg), a reversible monoamine oxidase A inhibitor, dose-dependently decreased heart rate and mean arterial pressure (in a concentration of 10 mg/kg) in alert NMRI mice and Sprague-Dawley rats. Nitric oxide synthase blockade with L-NAME attenuated tetrindol-induced bradycardia in rats and completely abolished this effect in mice.

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Authors and Affiliations

  1. Group of Pharmacology, Branch of the Institute of Bioorganic Chemistry, Russian Academy of Sciences, Pushchino, Moscow region, USSR

    V. A. Korshunov, A. N. Murashev & M. N. Ivashev

  2. Laboratory of Experimental Cardiac Pathology, Russian Cardiology Research-and-Production Complex, Russian Ministry of Health, USSR

    S. F. Dugin

  3. Department of Pharmacology, Faculty of Fundamental Medicine, M. V. Lomonosov Moscow State University, Moscow, USSR

    O. S. Medvedev

Authors
  1. V. A. Korshunov
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  2. A. N. Murashev
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  3. M. N. Ivashev
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  4. S. F. Dugin
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  5. O. S. Medvedev
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Corresponding author

Correspondence to A. N. Murashev.

Additional information

Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 130, No. 8, pp. 193–195, August, 2000

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Korshunov, V.A., Murashev, A.N., Ivashev, M.N. et al. Hemodynamic effects of tetrindol in alert normotensive mice and rats after blockade of nitric oxide synthesis. Bull Exp Biol Med 130, 777–779 (2000). https://doi.org/10.1007/BF02681944

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  • DOI: https://doi.org/10.1007/BF02681944

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