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Additivity and independence of neuroprotective effects of GABAA and GABAB receptor agonists in complete global cerebral ischemia

  • Biophysics and Biochemistry
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Bulletin of Experimental Biology and Medicine Aims and scope

Abstract

Neuroprotective effects of GABAB agonist baclofen and GABAA agonists THIP and muscimol are completely additive. GABAA and GABAB receptor antagonists block the neuroprotective effects of the corresponding agonists without cross-blocking. In fact, the blockade of combined effect of two agonists with selective GABAA and GABAB antagonists separately and in combination is not below the estimated value. Therefore, GABAA and GABAB receptor mechanisms of the neuroprotective effects independently and separately contribute to the improvement of brain resistance to global ischemia.

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References

  1. V. I. Kulinskii, and G. V. Mikhel'son,Eksp. Klin. Farmakol.,60, No. 1, 56–58 (1997).

    PubMed  CAS  Google Scholar 

  2. V. I. Kulinskii and G. V. Mikhel'son,Byull. Eksp. Biol. Med.,125, No. 2, 162–164 (1998).

    Article  CAS  Google Scholar 

  3. V. I. Kulinskii, G. V. Mikhle'son, G. Z. Sufianova,et al., Neirokhimiya,13, No. 1, 56–60 (1996).

    Google Scholar 

  4. V. I. Kulinskii, L. A. Usov, G. Z. Sufianova,et al., Eksp. Klin. Farmakol.,56, No. 6, 13–16 (1993).

    PubMed  CAS  Google Scholar 

  5. S. P. H. Alexander, A. Mead, and I. A. Peters,Trends Pharmacol. Sci.,33, Suppl., 33–35 (1998).

    Google Scholar 

  6. N. G. Bowery,Neurotransmission,15, No. 2, 3–11, 18 (1999).

    Google Scholar 

  7. H. Ito, Y. Watanabe, A. Isshiki,et al., Acta Anaesthesiol. Scand.,43, No. 2, 153–162 (1999).

    Article  PubMed  CAS  Google Scholar 

  8. C. Jackson-Friedman, P. D. Lyden, S. Nunez,et al., Exp. Neurol.,147, No. 2, 346–352 (1997).

    Article  PubMed  CAS  Google Scholar 

  9. P. D. Lyden,Neuroprotective Agents and Cerebral Ischemia, New York (1997), pp. 233–258.

  10. P. Malmberg-Aiello, M. Malcangio, L. Pizzighelli,et al., Pharm. Res.,22, No. 2, Suppl., 292 (1990).

    Google Scholar 

  11. T. P. Obrenovitch and D. A. Richards,Cerebrovasc. Brain Metab. Rev.,7, No. 1, 1–54 (1995).

    PubMed  CAS  Google Scholar 

  12. The GABA Receptors, Eds. S. J. Enna and N. G. Bowery, Totowa (1997).

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Authors and Affiliations

  1. Department of Biochemistry, Irkutsk Medical University, Irkutsk, USSR

    V. I. Kulinskii & G. V. Mikhel'son

Authors
  1. V. I. Kulinskii
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  2. G. V. Mikhel'son
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Correspondence to V. I. Kulinskii.

Additional information

Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 130, No. 8, pp. 187–189, August, 2000

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Kulinskii, V.I., Mikhel'son, G.V. Additivity and independence of neuroprotective effects of GABAA and GABAB receptor agonists in complete global cerebral ischemia. Bull Exp Biol Med 130, 772–774 (2000). https://doi.org/10.1007/BF02681942

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  • DOI: https://doi.org/10.1007/BF02681942

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