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Suppression of hemopoiesis during CCl4-induced hepatic fibrosis: Role of systemic endotoxemia

  • General Pathology and Pathophysiology
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Bulletin of Experimental Biology and Medicine Aims and scope

Abstract

CCl4-induced hepatic fibrosis in mice was accompanied by insufficiency of bone marrow myelo- and erythropoiesis. Polymyxin B completely abolished these changes. This phenomenon can be explained by the development of macrophage endotoxin tolerance during hepatic fibrosis.

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Authors and Affiliations

  1. Institute of Therapy, Siberian Division of the Russian Academy of Medical Sciences, Novosibirsk

    Ya. Sh. Shvarts, A. A. Zubakhin & M. I. Dushkin

Authors
  1. Ya. Sh. Shvarts
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  2. A. A. Zubakhin
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  3. M. I. Dushkin
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Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 130, No. 8, pp. 172–175, August, 2000

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Shvarts, Y.S., Zubakhin, A.A. & Dushkin, M.I. Suppression of hemopoiesis during CCl4-induced hepatic fibrosis: Role of systemic endotoxemia. Bull Exp Biol Med 130, 759–762 (2000). https://doi.org/10.1007/BF02681938

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  • DOI: https://doi.org/10.1007/BF02681938

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