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Emotional state and one-trial learning in OXYS rats with hereditarily elevated production of oxygen radicals

  • Physiology
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Bulletin of Experimental Biology and Medicine Aims and scope

Abstract

Comparative analysis of unconditioned and conditioned behavior of Wistar and prematurely aging OXYS rats revealed that the latter have significantly reduced locomotor and exploratory activities, increased anxiety in the elevated plus-maze test, spatial disorientation, and abnormal associative learning. OXYS rats can be used as a biological model for studying molecular, neurobiological, and neurochemical mechanisms of brain aging.

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Authors and Affiliations

  1. Institute of Physiology, Siberian Division of the Russian Academy of Medical Sciences, Novosibirsk

    L. V. Loskutova & N. G. Kolosova

  2. Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences, Novosibirsk

    L. V. Loskutova & N. G. Kolosova

Authors
  1. L. V. Loskutova
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  2. N. G. Kolosova
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Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 130, No. 8, pp. 155–158, August, 2000

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Loskutova, L.V., Kolosova, N.G. Emotional state and one-trial learning in OXYS rats with hereditarily elevated production of oxygen radicals. Bull Exp Biol Med 130, 746–748 (2000). https://doi.org/10.1007/BF02681934

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  • DOI: https://doi.org/10.1007/BF02681934

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