Abstract
Isolation and identification of rat brain protein regulated by serotonin-modulated protein SMP-69 is described. Intracerebral administration of anti-SMP-69 antibodies activates cerebral cortex cell genome and increases the content of electropheretic fraction 28. Intracerebral administration of isolated and purified protein to rats disturbed memory consolidation. It is concluded that nerve cells have a molecular switch regulating consolidation of memory traces.
Similar content being viewed by others
References
K. V. Anokhin and K. V. Sudakov,Uspekhi Fiziol. Nauk,24, No. 3, 53–70 (1993).
P. K. Anokhin,Articles on the Physiology of Functional Systems [in Russian], Moscow (1975).
L. A. Gromov, L. P. Syrovatskaya, and G. V. Ovinova,Zh. Vyssh. Nerv. Deyat.,41, No. 1, 60–65 (1991).
M. Klemens,Transcription and Translation. Techniques [in Russian], Moscow (1987), pp. 277–326.
S. A. Kozyrev, V. P. Nikitin, and V. V. Sherstnev,Byull. Eksp. Biol. Med.,104, No. 8, 139–141 (1987).
M. M. Mekhtiev, G. B. Eremenko, and A. A. Mekhtiev,Zh. Vyssh. Nervn. Deyat.,48, No. 6, 1107–1110 (1987).
J. Manly,Transcription and Translation. Techniques [Russian translation] Moscow (1987), pp. 89–110.
Systemogenesis and the Problems of Brain Genetics [in Russian], Moscow (1983).
A. Giuditta, M. V. Ambrosini, C. C. Perrone,et al., J. Neurogenet.,2, No. 2, 143–145 (1985).
J. Larson, G. Lynch, D. Games, and P. Seubert,Brain Res.,840, No. 102, 23–25 (1999).
J. S. Mogil and J. E. Grisel,Pain,77, No. 2, 107–128 (1999).
E. J. Nestler, M. B. Kelz, and J. Chen,Brain Res. 835, No. 1, 10–17 (1999).
P. M. Nola, R. Bell, and C. M. Regan,Neurosci. Lett.,79, No. 3, 346–350 (1987).
M.-L. Piront and R. Scmidt,Brain Res.,442, No. 1, 53–62 (1988).
T. Steckler, S. Weis, M. Sauvage,et al., Behav. Brain Res.,100, No. 1-2, 77–89 (1999).
Author information
Authors and Affiliations
Corresponding author
Additional information
Translated fromByulleten ‘Eksperimental’ noi Biologii i Meditsiny, Vol. 139, No. 8, pp. 147–150, August, 2000
Rights and permissions
About this article
Cite this article
Mekhtiev, A.A. Detection of protein with anticonsolidation properties in the rat brain. Bull Exp Biol Med 130, 739–742 (2000). https://doi.org/10.1007/BF02681932
Received:
Issue Date:
DOI: https://doi.org/10.1007/BF02681932