Abstract
Multiple bilateral microinjections of 5 μg picrotoxin (antagonist of chloride channels coupled with GABAA receptors) into the globus pallidus induced lethal seizures in some rats and impaired conditioned avoidance responses in survivors. Administration of 15 μg amphetamine into the rostral neostriatum prevented picrotoxin-induced lethal seizures and reduced its negative effects on active avoidance behavior. Activation of the neostriatal dopaminergic system in animals receiving no intrapallidal picrotoxin promoted recovery of conditioned responses after implantation procedure.
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Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 130, No. 8, 144–146, August, 2000
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Yakimovskii, A.F. Activation of neostriatal dopaminergic system in rats prevents toxic effects of picrotoxin administered into globus pallidus. Bull Exp Biol Med 130, 737–738 (2000). https://doi.org/10.1007/BF02681931
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DOI: https://doi.org/10.1007/BF02681931