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Association of glycogen storage disease 1b and Crohn disease: results of a North American survey

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Abstract

Glycogen storage disease (GSD)-1b has been associated with neutropenia and abnormalities of neutrophil function. Many individuals with GSD-1b manifest chronic gastrointestinal inflammation. Our study was performed to precisely establish the type, frequency, and spectrum of gastrointestinal disease in patients with GSD-1b. We established a medical database of 36 individuals affected with GSD-1b, utilizing patients at our center, disease registries, and direct contacts with North American referral centers specializing in genetic disorders. Records were reviewed, focusing on documentation of gastrointestinal involvement. Gastrointestinal symptoms or manifestations were present in approximately 75% of the patients, including chronic abdominal pain and diarrhea, perianal fistula or abscess, and oral aphthous ulceration. Of patients identified, 28% had documented inflammatory bowel disease (IBD) and an additional 22% of patients had symptoms highly suggestive of IBD, but had not undergone comprehensive diagnostic evaluation. Gastrointestinal involvement was found to be indistinguishable from idiopathic Crohn disease (CD) by detailed review of clinical, radiologic, endoscopic and histopathologic findings. Many patients had significant improvement or resolution of gastrointestinal disease in response to G-CSF treatment. The expression of CD in patients with GSD-1b may be delayed or prevented by G-CSF treatment.Conclusion: a strong association exists between glycogen storage disease type 1b and inflammatory bowel disease. A high index of suspicion for Crohn disease should be applied in evaluating patients with glycogen storage disease type 1b and intestinal symptoms. These results provide further support for the hypothesis that some forms of inflammatory bowel disease may result from impaired mucosal innate immunity. Additional investigations into the intestinal disease in glycogen storage disease type 1b may be directly relevant to the etiology and treatment of idiopathic Crohn disease.

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Abbreviations

CD :

Crohn disease

G-CSF :

granulocyte colony-stimulating factor

GSD :

glycogen storage disease

IBD :

inflammatory bowel disease

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Authors and Affiliations

  1. Washington University School of Medicine, 660 S. Euclid Ave., Campus Box 8124, 63110, St. Louis, MO, USA

    Brian K. Dieckgraefe, Joshua R. Korzenik, Asif Husain & Lisa Dieruf

Authors
  1. Brian K. Dieckgraefe
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  2. Joshua R. Korzenik
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  3. Asif Husain
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  4. Lisa Dieruf
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Corresponding author

Correspondence to Brian K. Dieckgraefe.

Additional information

Published online: 13 August 2002

On behalf of the North American Glycogen Storage Disease Study Group Members of the North American Glycogen Storage Disease Study Group: John Bellmont, Steve Cederbaum, Y.T. Chen, Peter Chenaille, Sechin Cho, George E. Hoganson, R. D. Holmes. Eric Hoover, Simon Horslen, James Keating, Douglas Kerr, Mark Ludman, Martin G. Martin, Dietrich Matern, Seymour Packman, Howard Parsons, Thomas Roe, Phil Rosenthal, C. R. Scott, Liz Shorey, Alfred E. Slonim, Charles Stanley, Micheline T. Ste-Marie, Robert D. Steiner, Holley Arp Swain, Steven Werlin, Joseph I. Wolfsdorf, and R. C. Woodman.

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Dieckgraefe, B.K., Korzenik, J.R., Husain, A. et al. Association of glycogen storage disease 1b and Crohn disease: results of a North American survey. Eur J Pediatr 161, S88–S92 (2002). https://doi.org/10.1007/BF02680002

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