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Determination of the content of endogenic porphyrins in children and adolescents with thyroid pathology

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Journal of Applied Spectroscopy Aims and scope

Abstract

The aim of the present work was to use the fluorescence method for elucidating the laws governing porphyrin exchange in children with thyroid pathology to estimate the possibility of creating in future nontradiational approaches to the diagnosis of oncologic diseases. A systematic investigation of the level of photo- and coproporphyrins in the erythrocytes of children and adolescents of from 8 to 17 years old with thyroid pathology (cancer, ganglia, autoimmune thyroiditis) is carried out. A control group of the same ages was examined for comparison. It is shown than in all of the pathologies considered one observes an individual character of porphyrin variation, which affects the content of protoporphyrin and corproporphyrin in erythrocytes. A decrease in the level of endogenic porphyrins in the blood of children with malignant tumors is discovered.

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Authors
  1. L. A. Grubina
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Institute of Molecular and Atomic Physics of the Academy of Sciences of Belarus, 70, Skorina Ave., Minsk, 220072, Belarus. Translated from Zhurnal Prikladnoi Spektroskopii, Vol. 64, No. 6, pp. 748–752, November–December, 1997.

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Grubina, L.A. Determination of the content of endogenic porphyrins in children and adolescents with thyroid pathology. J Appl Spectrosc 64, 759–763 (1997). https://doi.org/10.1007/BF02678858

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  • DOI: https://doi.org/10.1007/BF02678858

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