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Quantitation of intermolecular dipolar effects in NMR spectroscopy and high order MSE MR imaging

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Abstract

An analytical expression for intermolecular dipolar effects was derived for the CRAZED sequence with an arbitrary flip angle of the second RF pulse and time-varying gradients. A combination of the demagnetizing field theory and product operator formalism was utilized in the derivation. It is demonstrated that the time-averaged, not instantaneous, orientation of the applied gradients determines the contributions of long-range intermolecular dipole effects. An imaging sequence to detect intermolecular dipolar effects was designed. The second- and third-order multiple spin echo (MSE) NMR signals of swine muscle were observed and were found to be in good agreement with the theoretical predictions. MSE images of a water phantom withnth orders (n=−2, −3, −4, and − 5) were also obtained, and their relative signal intensities and optimized TE values were elucidated and compared with the theoretical prediction.

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Authors and Affiliations

  1. Department of Radiology, University of Rochester Medical Center, University of Rochester, 601 Elmwood Avenue, Box 648, 14642-8648, Rochester, NY, USA

    Zhong Chen & Jianhui Zhong

  2. Department of Biochemistry and Biophysics, University of Rochester, 14642, Rochester, NY, USA

    Scott D. Kennedy

  3. Department of Biomedical Engineering, University of Rochester, 14642, Rochester, NY, USA

    Jianhui Zhong

  4. Department of Chemistry, State Key Laboratory for Physical Chemistry of Solid Surface, Xiamen University, 361005, Xiamen, Fujian, Peope’s Republic of China

    Zhong Chen

Authors
  1. Zhong Chen
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  2. Scott D. Kennedy
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  3. Jianhui Zhong
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Correspondence to Jianhui Zhong.

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Chen, Z., Kennedy, S.D. & Zhong, J. Quantitation of intermolecular dipolar effects in NMR spectroscopy and high order MSE MR imaging. MAGMA 11, 122–128 (2000). https://doi.org/10.1007/BF02678475

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  • DOI: https://doi.org/10.1007/BF02678475

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