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Heat shock proteins and the antitumor T cell response

  • Published:
Biotherapy

Abstract

Heat shock proteins (HSP) have been shown to participate in the antitumor T cell response. First, HSP play a crucial role in the intracellular pathway for antigen processing where HSP can make complexes with a broad spectrum of cellular proteins and peptides through their chaperone functions. In this pathway, macrophages are required for processing the chaperoned peptides to make stable molecules with the major histocompatibility complex (MHC) class I molecules, even when HSP-peptide complexes are exogenously administered. Through this pathway, vaccination with HSP-peptide complexes is thus able to elicit the response of CD8+ T cells specific for the chaperoned peptides. These findings suggest an essential role of HSP in ‘cross-priming’ and their usefulness for antitumor vaccination with tumor peptides. Second, HSP have been suggested to be expressed on the cell surface by transformation and, in addition, to function as antigen-presenting molecules for double negative T cells. Third, HSP derived from tumor cells have reportedly been recognized by T cells with either T cell receptor (TCR)-αβ or TCR-γδ. These lines of evidence therefore indicate that HSP may be potentially promising target molecules for antitumor T cell immunotherapy.

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Abbreviations

APC:

antigen-presenting cell(s)

CTL:

cytotoxic T lymphocyte(s)

ER:

endoplasmic reticulum

HLA:

human leukocyte antigen

HSP:

heat shock protein(s)

MHC:

major histocompatibility complex

TAP:

transporter associated with antigen processing

TCR:

T cell receptor

TRA:

tumor rejection antigen

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Authors and Affiliations

  1. Departments of Virology and Immunology, Medical Institute of Bioregulation, Kyushu University, 812-82, Fukuoka, Japan

    Mamoru Harada, Genki Kimura & Kikuo Nomoto

Authors
  1. Mamoru Harada
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  2. Genki Kimura
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  3. Kikuo Nomoto
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Correspondence to Mamoru Harada.

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Harada, M., Kimura, G. & Nomoto, K. Heat shock proteins and the antitumor T cell response. Biotherapy 10, 229–235 (1998). https://doi.org/10.1007/BF02678301

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