Abstract
We generalize the results of study of the application of ferromagnetic particles in medicine. Metallic iron, iron oxides, and also ferrites with different structures and others are used. It has been established that it is advantageous to use very fine iron particles with particle size 0.1–0.25 μm and a combination of physicochemical and biomedical properties.
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References
O. G. Cherkasova, V. I. Petrov, and B. A. Rudenko, “Magnetic dosage forms in medicine,” Farmatsiya, No. 4, 70–74 (1986).
Yu. L. Raikher, M. I. Shliomis, and V. A. Frank, “Application of magnetic fluids in clinical medicine,” Klin. Khirurgiya, No. 1, 73–77 (1988).
Application of Magnetic Fluids in Biology and Medicine [in Russian], Sukhumi (1985).
B. E. Levin, Yu. D. Tret’yakov, and L. M. Letyuk, Physicochemical Principles of Ferrite Synthesis: Properties and Application [in Russian], Nauka, Moscow (1979).
Magnetobiology and Magnetotherapy [in Russian], Sofiya (1989).
Magnetobiology and Magnetotherapy in Medicine [in Russian], Vitebsk (1980).
R. S. Molday and D. Mackenzie, “Immunospecific ferromagnetic iron-dextran reagents for the labeling and magnetic separation of cells,” J. Immunol. Methods,52, 353–367 (1982).
V. S. Ulashchik, S. M. Mankevich, and L. I. Savchenko, Combining Drugs and Therapeutic Physical Factors: Methodological Recommendations [in Russian], Minsk (1985).
M. I. Papisov, V. Yu. Savel’ev, V. B. Sergienko, and V. P. Torchilin, Biokinetics of Magnetic Carriers for Directed Drug Transport. Antibiotics and Chemotherapy [in Russian], Meditsina, Moscow (1988), No. 10, pp. 744–751.
A. G. Alekseev and A. E. Kornev, Magnetic Elastomers [in Russian], Zdorov’e, Moscow (1989).
A. A. Preobrazhenskii and E. G. Bishard, Magnetic Materials and Elements [in Russian], Zdorov’e, Moscow (1986).
V. I. Rymarchuk, A. G. Malenkov, L. A. Radkevich, and V. I. Sarbash, “Physical principles of the application of ferromagnetics introduced into the body,” Biofizika,35, No. 1, 145–154 (1990).
C. Heck, Magnetic Materials and Their Applications [Russian translation], Mashinostroenie, Moscow (1973).
O. G. Cherkasova, “A magnetic field and magnetic dosage forms in medicine,” Khimiko-Farmats. Zh.,27, No. 5, 4–12 (1991).
D. D. Mishin, Magnetic Materials [in Russian], Zdorov’e, Moscow (1981).
W. C. Dewey, in: Abstracts, Second All-Union Symposium with International Participation on Hyperthermia in Oncology, obninsk (1990), Vol. 2, pp. 88–96.
L. E. Belousova, “Possibility of slowing down and stopping blood by a magnetic field,” Biofizika,10, No. 2, 365–367 (1965).
N. I. Postryygin and V. S. Cherevko, Magnetotherapy in Combination Treatment of Burn Injuries [in Russian], Ozhogovaya Bolezn’, Kiev (1986)
I. L. Degen, “Therapeutic effect of magnetic fields in surgery,” Klinicheskaya Khirugiya, No. 3, 73–79 (1971).
B. A. Ivanov and M. T. Tamarina, “Magnetolaser therapy for trophic ulcers and persistent slow-healing injuries,” Voenno-Med. Zh., No. 8, 30–34 (1992).
A. S. Mavrychev and V. E. Fertman, “State of the art and prospects for application of magnetic particles in oncology,” Voprosy Onkologii,37, 11–17 (1991).
Yu. I. Fedorov, E. B. Burlakova, and I. P. Ol’khovskya, “Possible application of highly dispersed metal powders for introduction into the body of animals,” Dokl. Akad. Nauk SSSR,248, No. 5, 1277–1290 (1979).
Biomedical Principles of the Application of Magnetic Fields in Health Care Practice [in Russian], Minzdrav, Leningrad (1989).
É. M. Natanson, Metal Powders and Their Application [in Russian], Nauk. Dumka, Kiev (1957).
G. V. Lisichkin, V. A. Tertykh, and P. N. Nesterenko, “Mineral supports with grafted surface compounds: Aspects of practical use,” Zh. Vses. Khim. Obshch. im. D. I. Mendeleeva,36, No. 6, 697–705 (1991).
Jpn. Pat. 6157517, Publ. 1993.
Byulleten’ Vses. Nauch. Tsentra Akad. Med. Nauk SSSR, No. 1 (1984).
G. M. Barenboim and A. G. Malenkov, Biologically Active Compounds. New Search Principles [in Russian], Nauka, Moscow (1986).
G. T. Kurbatova, O. M. Mikhailik, and E. I. Oranskaya, “Preparation of hydrolytically stable iron-dextran micro-particles,” Ukr. Khim. Zh., No. 4, 77–79 (1993).
N. A. Luk’yanchikova, A. I. Autenshlyus, and N. A. Brusensov, “Immobilization of immunoglobulins on magnetically responsive supports,” Byull. Sib. Otdel., Akad. Med. Nauk SSSR, No. 1, 17–21 (1989).
K. J. Widder, G. Flouret, and A. E. Senyei, “Magnetic microspheres: Synthesis of a novel parenteral drug carrier,” J. Pharm. Sci.,68, 79–82 (1979).
K. S. Ternovoi and A. E. Derzhavin, “Some aspects of the application of finely dispersed iron lakes in biology and medicine,” Vrach. Delo, No. 5, 4–14 (1983).
E. E. Bibik and O. V. Bizunov, “Achievements in synthesis and Application of ferromagnetic fluids. Reviews of Electronic technology,” TsNII Élektronika (1979), Ser. 6, No. 7, pp. 3–17.
A. Engelhardt, in: Hyperthermic Oncology. Summary Papers, Taylor & Francis, London (1989), Vol. 2, pp. 69–74.
Problems in Creation and Application of X-Ray Contrast Media in Oncology [in Russian], Meditsina i Zdavokhranenie, Moscow (1985).
T. M. Shvets, E. P. Zhelibo, Z. M. Mel’nichenko, and V. P. Vasilenko, Physical Chemistry of Highly dispersed Ferromagnetics [in Russian], Nauk. Dumka, Kiev (1985).
J. B. Goodenough, Magnetism and the Chemical Bond [Russian translation], Nauk. Dumka, Kiev (1985).
S. W. Charles, Magnetic Fluids and Powders: New Technological Materials, European Advanced Course of UNESCO, Minsk (1991).
A. F. Psyb, I. S. Amasan, B. M. Berkovsky, et al., “Magnetic fluids as contrast media,” J. Magnetism & Magnetic Mater.,39, 183–186 (1983).
É. F. Blum, “State of the art of research and prospects for application of liquid magnetizable media,” Magn. Gidrodin., No. 3, 145–148 (1977).
A. A. Serdan, A. G. Lyashenko, S. Yu. Bogoslovskii, and P. N. Nesterenko, Medbioékonomika, Moscow (1990), No. 4, pp. 41–49.
D. B. Kirpotin, A. F. Orlovskii, Yu. A. Motorin, and K. L. Gladilin, Riga Conference on Magnetic Hydrodynamics, Salaspils (1987).
“Synthesis of highly dispersed metal powders,” in: Abstracts, All-Union Scientific and Technical Conference on Metal Ceramic Materials and Articles [in Russian], Erevan (1973).
Scientific Works, Riga Scientific Research Institute of Traumatology and Orthopedics [in Russian] Riga (1974), Vol. 12.
V. N. Bugaev, Yu. A. Buevich, and A. I. Ivanov, “Theory of magnetic properties of ferrocolloids,” Magn. Gidrodin., No. 1, 58–62 (1989).
A. U. Ivanov, “Magnetostatic properties of moderately concentrated ferrocolloids,” Magn. Gidrodin., No. 4, 39–46 (1992).
“Method for obtaining highly disperse electrolytic iron,” Inventor’s Certificate 1394749 USSR, Otkrytiya. Izobret. (1986).
T. M. Shvets, Z. M. mel’nichenko, N. A. Zemlyak, et al., “Applications of magnetically guided sorbents for treatment of purulent cavities,” in: Abstracts, Fifth Ukrainian Conference of Surgeons, Simferopol’ (1983), pp. 94–96.
T. M. Shvets, Z. M. Mel’nichenko, N. A. Zemlyak, and É. V. Gorshevikova, “Antimicrobial action of highly disperse iron,” Élektron. Obrab. Mater., No. 5, 72–74 (1986).
T. M. Shvets, N. F. Kushchevskaya, Z. M. Mel’nichenko, and T. S. Maksimenko, “Study of the corrosion resistance of highly disperse iron,” Poroshk. Metall., Nos. 7–8, 100–104 (1994).
N. F. Kushchevskaya, T. M. Shvets, and V. E. Polyakov, “Investigation of the reaction between highly disperse iron and water,” Poroshk. Metall., Nos. 5–6, 111–112 (1995).
N. F. Kushchevskaya, L. G. Borodina, and V. A. Shvitai, “Investigation of the thermal stability of highly disperse iron,” Poroshk. Metall., Nos. 11–12, 37–40 (1994).
R. I. Gvozdyak, T. M. Shvets’, N. F. Kushchevs’ka, and R. O. Denis, “Antibacterial activity of highly disperse iron,” Mikrobiol. Zh.,58, No. 6, 45–49 (1996).
V. A. Baraboy, Z. D. Savtsova, T. M. Shvets, and N. F. Kushcheskaya, “Experimental analysis of tumor cells exposed to highly-dispersed ferromagnetics,” Experimental Oncology,18, No. 4, 413–418 (1996).
T. M. Shvets’, N. F. Kushchevs’ka, and E. O. Grigor’ev, “New Materials in Neurooncology,” in: Modern Aspects of Medicine [in Ukrainian], L’vov (1997), pp. 55–57.
T. M. Shvets, N. F. Kushchevskaya, and A. V. Klochko, “Study of the feasibility of using highly disperse iron for directed thyroxine transport,” Vracheb. Delo, No. 1, 15–17 (1997).
M. I. Simorot, T. M. Shvets’, N. F. Kushchevs’ka, et al., “Applied aspects of the results of biologically active,” Zbirnik MOZU, Kiev (1994), pp. 166–169.
M. I. Simorot, T. M. Shvets’, N. F. Kushchevs’ka et al., Proposition No. 2921, “Method for treating purulent wounds using composite ferromagnetic materials,” 12.23.96.
M. M. Shabargina, A. I. Tsapin, A. G. Malinkov, and A. R. Vanin, “Behavior of magnetic particles of metallic iron in the body of animals,” Biofizika,35, No. 6, 985–990 (1990).
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Institute of Colloid Chemistry and Chemistry of Water, Ukrainian Academy of Sciences, Kiev. Translated from Poroshkovaya Metallurgiya, Nos. 11–12, pp. 116–120, November–December, 1997.
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Kushchevskaya, N.F. Use of ferromagnetic particles in medicine. Powder Metall Met Ceram 36, 668–672 (1997). https://doi.org/10.1007/BF02676160
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DOI: https://doi.org/10.1007/BF02676160