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Cyanide-induced free radical production and lipid peroxidation in rat brain homogenate is reduced by aspirin

Metabolic Brain Disease volume 15, pages 203–210 (2000)Cite this article

Abstract

The neuroprotective properties of aspirin were investigated using cyanide-induced neurotoxicity as model. Cyanide, a known neurotoxic agent significantly increased lipid peroxidation and superoxide anion levels in rat brain homogenate in a concentration-dependent manner (0.25–1.0 mM). When homogenate, containing 1.0 mM KCN was cotreated with aspirin (1.0 mM) there was a significant decrease in lipid peroxidation. Aspirin (0.5 mM and 1.0 mM) also significantly reduced KCN-induced superoxide anion generation. The results of the present report therefore indicate a neuroprotective role for aspirin.

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Affiliations

  1. Faculty of Pharmacy, Rhodes University, P.O. Box 94, 6140, Grahamstown, South Africa

    Santy Daya, Roderick B. Walker & Shailendra Anoopkumar-Dukie

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  1. Santy Daya
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  2. Roderick B. Walker
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  3. Shailendra Anoopkumar-Dukie
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Correspondence to Santy Daya.

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Daya, S., Walker, R.B. & Anoopkumar-Dukie, S. Cyanide-induced free radical production and lipid peroxidation in rat brain homogenate is reduced by aspirin. Metab Brain Dis 15, 203–210 (2000). https://doi.org/10.1007/BF02674529

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  • DOI: https://doi.org/10.1007/BF02674529

Keywords

  • Cyanide
  • aspirin
  • free radical
  • neurotoxicity
  • lipid peroxidation
  • superoxide anion