Chinese Journal of Cancer Research

, Volume 7, Issue 4, pp 298–304 | Cite as

Reproducibility of esophageal biopsy sampling procedure

  • Zhou Qi
  • Wang Lidong
  • Guo Reiyiong
  • Xing Ying
  • Zhang Baocai
  • Li Qiju
Clinical Observations


The main objective of this study was to evaluate the biopsy sampling procedure in the detection of esophageal precancerous lesions. Biopsies were taken one from the middle-third and one from the lower-third of the esophagus of 28 subjects from a high incidence area for esophageal cancer in Henan, China. The sampling procedure was repeated on the same subjects 10 days later. During this period, all subjects followed their usual dietary habits. Histopathological analysis showed that in the second sampling from the middle-third of the esophagus, 24% of the subjects had less severe lesions, 28% had more severe lesions and 48% had the same severity of lesions. From the lower-third of the esphagus, 48% of the subjects had less severe lesions, 16% had more severe lesions and 32% had the same severity of lesions. These results suggest that the reproducibility of biopsy procedure could be a factor for the previously reported “reversion” or “progression” of precancerous lesions in follow-up studies.

Key words

Esophagus Biopsy sampling procedure Precancerous lesions 


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  1. 1.
    China, Cancer(Phil) 1988;62:551.Google Scholar
  2. 2.
    Goldman H, Antonioli DA. Mucosal biopsy of the esophagus, stomach, and proximal duodenum. Human Pathol 1982;13:423.CrossRefGoogle Scholar
  3. 3.
    Munoz N, Crespi M, Grassi A, et al. Precursor lesions of oesophageal cancer in high-risk populations in Iran and China. Lancet 1982;1:876.PubMedCrossRefGoogle Scholar
  4. 4.
    Robertson CS, Mayberry JF, Nichlson DA, et al. Value of Qiu SL, Yang Gr. Precursor lesions of esophageal cancer in high-risk populations in Henan Province, endoscopic surveillance in the detection of neoplastic change in Barrett's oesophagus. Br J Surg 1988;75:760.PubMedCrossRefGoogle Scholar
  5. 5.
    Crespi M, Munoz N, Grassi A, et al. Precursor lesions of oesophageal cancer in a low-risk population in China: Com-parison with high-risk populations. Int J Cancer 1984;34:599.PubMedCrossRefGoogle Scholar
  6. 6.
    Wang LD, Qiu SL, Yang GR, et al. A randomized double-blind intervention study on the effect of calcium supplementation on esophageal precancerous lesions in a high-risk population in China. Cancer Epidemiol Biomarkers & Prev. 1993;2:71.Google Scholar
  7. 7.
    Munoz N, Wahrendorf J, Lu JB, et al. No effect of riboflavin, retinol, and zinc on prevalence of precancerous lesions of oesophagus Randomized double-blind intervention study in high-risk population of China. Lancet 1985;1:111.CrossRefGoogle Scholar
  8. 8.
    El-Guneid A, El-Sherif AM, Murray-Lyon IM, et al. Effect of chewing qat on mucosal histology and prevalence of helico-bacter pylori in the oesophagus, stomach and duodenum of Yemini patients. Histopathology 1991;19:437.PubMedCrossRefGoogle Scholar
  9. 9.
    Jarvis L, Dent J, Whitehead R. Morphometric assessment of reflux oesophagitis in fibreoptic biopsy specimens. J Clin Pathol 1985;38:44.PubMedCrossRefGoogle Scholar
  10. 10.
    Reid BJ, Weinstein WM, Lewin KJ, et al. Endoscopic biopsy can detect high-grade dysplasia or early adenocarcinoma in Barrett's esophagus without grossly recognizable neoplastic lesions. Gastroenterology 1988;94:81.PubMedGoogle Scholar
  11. 11.
    Seefeld U, Krejs GJ, Siebenmann RE, et al. Esophageal his-tology in gastroesophageal reflux: Morphometric findings in suction biopsies. Am J Dig Dis 1977;11:956.CrossRefGoogle Scholar
  12. 12.
    Ashworth MT, Nash JRG, Ellis A, et al. Abnormalities of differentiation and maturation in the oesophageal squamous epithelium of patients with tylosis: Morphological features. Histopathology 1991;19:303.PubMedCrossRefGoogle Scholar
  13. 13.
    Winter HS, Madara JL, Stafford RJ, et al. Intraepithelial eosinophils: A new diagnostic criterion for reflux esophagitis. Gastroenterology 1982;83:818.PubMedGoogle Scholar
  14. 14.
    Monnier P, Savary M, Pasche R, et al. Intraepithelial carci-noma of the oesophagus: Endoscopic morphology. Endo-scopy 1981;13:185.CrossRefGoogle Scholar
  15. 15.
    Maeta M, Koga S, Shimizu N, et al. Carcinogenic potential of the non-cancerous epithelium in patients with oesophageal cancer. Br J Surg 1988;75:531.PubMedCrossRefGoogle Scholar
  16. 16.
    Jaskiewicz K, Banach L, Mafungo V, et al. Oesophageal mucosa in a population at risk of oesophageal cancer: Post-mortem studies. Int J Cancer 1992;50:32.PubMedCrossRefGoogle Scholar
  17. 17.
    Ohta H, Nakazawa S, Segawa K, et al. Distribution of epithelial dysplasia in the cancerous esophagus. Scand J Gastroenterol 1986;21:392.PubMedGoogle Scholar
  18. 18.
    Nagamatsu M, Mori M, Kuwano H, et al. Serial histologic investigation of squamous epithelial dysplasia associated with carcinoma of the esophagus. Cancer 1992;69:1094.PubMedCrossRefGoogle Scholar
  19. 19.
    Lal N, Bhasin DK, Malik AK, et al. Optimal number of biopsy specimens in the diagnosis of carcinoma of the oesophagus. Gut 1992;33:724.PubMedGoogle Scholar
  20. 20.
    O'Donoghue JO, Waldron R, Gough D, et al. An analysis of the diagnostic accuracy of endoscopic biopsy and cytology in the detection of oesophageal malignancy. Eur J Surg Oncol 1992;18:332.PubMedGoogle Scholar

Copyright information

© Chinese Journal of Cancer Research 1995

Authors and Affiliations

  • Zhou Qi
    • 1
  • Wang Lidong
    • 1
  • Guo Reiyiong
    • 2
  • Xing Ying
    • 3
  • Zhang Baocai
    • 3
    • 4
  • Li Qiju
    • 3
    • 4
  1. 1.Laboratory for Cancer ResearchHenan Medical UniversityZhengzhouChina
  2. 2.Nanyang Medical SchoolChina
  3. 3.Xinxiang Medical CollegeChina
  4. 4.Xinxiang central HospitalChina

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