Effect of superoxide dismutase and diethyldi-thicarbamate on the induction of squamous cell carcinoma of lung withmethyl-cholanthren in rats
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The squamous cell carcinoma of lung was induced with methylcholanthrene (MCA) in iodized oil in wistar rts. During the development of the cancer, the animals were given superoxide dismutase (SOD) or its inhibitor diethyldio-carbamate (DDC). In DDC group, 3 out of 50 rats developed cancer and 4 developed atypical hyperplasia of hronchial epithelium within 35 to 40 days. In SOD group, no cancer developed in all of the 52 rats, and only one had atypical hyperplasia in the lungs. Only one of 42 control rats had cancer and 2 rats had atypical hyperplasia of bronchial epithelium. The difference in cancer frequency between groups DDC and SOD was significant (P<0.05). The results suggest that there is a synergism between DDC and MCA in the induction of lung cancer, while SOD can inhibit MCA-induced lung cancer development. The mechanism of the effect of SOD and DDC was discussed.
Key wordsSuperoxide dismutase (SOD) Induced lung cancer Squamous cell carcinoma Diethyldithio-carbamate (DDC) Methylcholan-threne (MCA)
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