Chinese Journal of Cancer Research

, Volume 7, Issue 4, pp 258–261 | Cite as

The finding of patients suffering from naso-pharyngeal carcinoma (NPC) who contacted with the hexamethylphosphoramide (HMPA) for a long term

  • Huang Di
  • Zhang Jinming
  • Liang Xiaoman
Basic Investigations


In 1975, it was found that the HMPA could induce the nasal tumors in the rats, the carcinogenicity and the latency were dose correlated with the HMPA concentration, it was estimated by the National Institute for occupation Safety Health that about 5,000 people were occupationally exposed to HMPA in 1975, and more than 90% exposures are in research laboratories. Since then, no one patient suffering from NPC or nasal tumors has been found. In 1987, in a mass survey of Antibodies to Epstein-Barr Virus specific DNase (EDAb). Authors found that there were eight persons who had a long term contact with HMPA (8–10 years) in 1970–1980 in Guangzhou Chemical Engineering Institute. 2 of the 8 were EDAb positive (high titre) but the nasopharyngeal cavity were not found any abnormal. Owing to the history of contact with HMPA and a vigorous elevation of EDAb titre in the duration of 2.5 years' follow up was observed. There 2 persons were considered as a high risk population of NPC and a “Blind Biopsy” of nasopharynx was suggested. A diagnosis of poorly differentiated squamous carcinoma confirmed pathologically. The clinical stage of these 2 patients were stage 1(T1N0M0) and were treated with radiotherapy and live very well till now. The results suggested that the HMPA might induced human nasopharyngeal carcinoma.


Nasopharyngeal Carcinoma Squamous Carcinoma Term Contact Mass Survey Human Nasopharyngeal Carcinoma 
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  1. 1.
    Zapp Ja Jr. Hexamethylphosphoramide (HMPA) Possible Carcinogen. Science 1975; 190 (4213): 422.Google Scholar
  2. 2.
    Lee KP. Induction of Nasal Tumours in Rats Exposed to Hexamethylphosphoramide by Inhalation. J Natl Cancer Institute 1982; 68(1):157.Google Scholar
  3. 3.
    Lee KP, Trochemowicz HJ. Metaplastic Changes of Nasal Respiratory Epithelium in Rats Exposed to HMPA by Inhalation. Am J Pathol 1982; 106(1): 8.PubMedGoogle Scholar
  4. 4.
    Lee KP, Trochemowicz HJ. Morphogenesis of Nasal Tumors in Rats Wxposed to Hexamethylpho-sphoramide by Inhalation. Environ Res 1984; 33(1):106.PubMedCrossRefGoogle Scholar
  5. 5.
    Dahl A, Brezinski DA. Inhibition of Rabbit Nasal And Hepatic Cytocheome P-450-Dependent Hexzamethylphosphoramide (HMPA) N-demethylase by Methylenedioxyphenyl Compounds. Biochem Pharmacol 1985; 35(5):631.CrossRefGoogle Scholar
  6. 6.
    Zijistra JA, Brusaee J, Van der Gen A, et al. Importance of Mutiple Hydroxylated Metabolites in Hexamethylphosphoramide (HMPA)-Mediated Mutagenesis in Drospophila Melanogaster. Mutat Res 1989; 212(2):193.Google Scholar
  7. 7.
    Din XX, Coon MJ. Immunochemical Characterization of Multiple from of Cytochrome P-450 in Rabbit Nasal Microsomes And Evidence of Tissue-Specific Expression of P453s Nma and Nmb. Mol Pharmacol 1990; 37(4):489.Google Scholar
  8. 8.
    Armastrong DR, Bennett S, Davidson MG, et al. A Possible Model to Explain The Carcinogenicity of HMPA. J Chem Soc chem Commun 1992;1992(3):262.CrossRefGoogle Scholar
  9. 9.
    J William Lloyd, SdD. Hexamethylphosphoric Triamide (HMPA). Am Ind Hug Assoc J 1975; 36(12):917.Google Scholar
  10. 10.
    Cheng YC, Chen Jenyang, Ranald Glaser, et al. Frequency And Level of Antibodies to Epstein-Barr Virus-Specific Dnase are Elevated in Patients with Nasopharyngeal Carcinoma. Proc Natl Acad Sci USA 1980; 77:6162.PubMedCrossRefGoogle Scholar
  11. 11.
  12. 12.

Copyright information

© Chinese Journal of Cancer Research 1995

Authors and Affiliations

  • Huang Di
    • 1
  • Zhang Jinming
    • 2
  • Liang Xiaoman
    • 3
  1. 1.Department of BiochemistrySun Yat-sen University of Medical SciencesGuangzhou
  2. 2.Department of Head and neck TumorSun Yat-sen University of Medical SciencesGuangzhou
  3. 3.Department of pathology, Cancer Institute/Tumor HospitalSun Yat-sen University of Medical SciencesGuangzhou

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