Skip to main content
Log in

The finding of patients suffering from naso-pharyngeal carcinoma (NPC) who contacted with the hexamethylphosphoramide (HMPA) for a long term

  • Basic Investigations
  • Published:
Chinese Journal of Cancer Research

Abstract

In 1975, it was found that the HMPA could induce the nasal tumors in the rats, the carcinogenicity and the latency were dose correlated with the HMPA concentration, it was estimated by the National Institute for occupation Safety Health that about 5,000 people were occupationally exposed to HMPA in 1975, and more than 90% exposures are in research laboratories. Since then, no one patient suffering from NPC or nasal tumors has been found. In 1987, in a mass survey of Antibodies to Epstein-Barr Virus specific DNase (EDAb). Authors found that there were eight persons who had a long term contact with HMPA (8–10 years) in 1970–1980 in Guangzhou Chemical Engineering Institute. 2 of the 8 were EDAb positive (high titre) but the nasopharyngeal cavity were not found any abnormal. Owing to the history of contact with HMPA and a vigorous elevation of EDAb titre in the duration of 2.5 years' follow up was observed. There 2 persons were considered as a high risk population of NPC and a “Blind Biopsy” of nasopharynx was suggested. A diagnosis of poorly differentiated squamous carcinoma confirmed pathologically. The clinical stage of these 2 patients were stage 1(T1N0M0) and were treated with radiotherapy and live very well till now. The results suggested that the HMPA might induced human nasopharyngeal carcinoma.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Zapp Ja Jr. Hexamethylphosphoramide (HMPA) Possible Carcinogen. Science 1975; 190 (4213): 422.

    Google Scholar 

  2. Lee KP. Induction of Nasal Tumours in Rats Exposed to Hexamethylphosphoramide by Inhalation. J Natl Cancer Institute 1982; 68(1):157.

    CAS  Google Scholar 

  3. Lee KP, Trochemowicz HJ. Metaplastic Changes of Nasal Respiratory Epithelium in Rats Exposed to HMPA by Inhalation. Am J Pathol 1982; 106(1): 8.

    PubMed  CAS  Google Scholar 

  4. Lee KP, Trochemowicz HJ. Morphogenesis of Nasal Tumors in Rats Wxposed to Hexamethylpho-sphoramide by Inhalation. Environ Res 1984; 33(1):106.

    Article  PubMed  Google Scholar 

  5. Dahl A, Brezinski DA. Inhibition of Rabbit Nasal And Hepatic Cytocheome P-450-Dependent Hexzamethylphosphoramide (HMPA) N-demethylase by Methylenedioxyphenyl Compounds. Biochem Pharmacol 1985; 35(5):631.

    Article  Google Scholar 

  6. Zijistra JA, Brusaee J, Van der Gen A, et al. Importance of Mutiple Hydroxylated Metabolites in Hexamethylphosphoramide (HMPA)-Mediated Mutagenesis in Drospophila Melanogaster. Mutat Res 1989; 212(2):193.

    Google Scholar 

  7. Din XX, Coon MJ. Immunochemical Characterization of Multiple from of Cytochrome P-450 in Rabbit Nasal Microsomes And Evidence of Tissue-Specific Expression of P453s Nma and Nmb. Mol Pharmacol 1990; 37(4):489.

    Google Scholar 

  8. Armastrong DR, Bennett S, Davidson MG, et al. A Possible Model to Explain The Carcinogenicity of HMPA. J Chem Soc chem Commun 1992;1992(3):262.

    Article  Google Scholar 

  9. J William Lloyd, SdD. Hexamethylphosphoric Triamide (HMPA). Am Ind Hug Assoc J 1975; 36(12):917.

    Google Scholar 

  10. Cheng YC, Chen Jenyang, Ranald Glaser, et al. Frequency And Level of Antibodies to Epstein-Barr Virus-Specific Dnase are Elevated in Patients with Nasopharyngeal Carcinoma. Proc Natl Acad Sci USA 1980; 77:6162.

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Additional information

This program was supportyed financially by the Chinese National Fundation of Natural Sciences (No. 38670456)

Rights and permissions

Reprints and permissions

About this article

Cite this article

Di, H., Jinming, Z. & Xiaoman, L. The finding of patients suffering from naso-pharyngeal carcinoma (NPC) who contacted with the hexamethylphosphoramide (HMPA) for a long term. Chinese Journal of Cancer Research 7, 258–261 (1995). https://doi.org/10.1007/BF02672788

Download citation

  • Received:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF02672788

Keywords

Navigation