Detoxifying effect of Lisheng-Se on CDDP and its relation to metallothionein induction
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The effects of Lisheng-Se (Seleninized wheat germ) on metallothionein (MT) induction, lethal systemic toxicity, hemotoxicity and anticancer activity of cisplatin (CDDP), were investigated in mice. The systemic toxicity of CDDP was significantly reduced by preadministration of Lisheng-Se (P<0.05 orP<0.01). The protective effects were better than its inorganic form (Na2 SeO3) and Bi (BSN), (0.05<P<0.1). The MT level in the liver, kidney and tumor tissues of mice treated with one of those compounds was determined. The liver and kidney (P<0.01 andP<0.05). It was just in conformity with the conclusion that the best protective effect appeared in the groups treated with Lisheng-Se. These result suggest that increased MT synthesis in the liver and kidney may be involved in the protective effects of Lashing-Se tested on the lethal toxicity, nephrotoxicity and hemotoxicity produced by CDDP. The experiments also showed that Lisheng-Se did not affect the anticancer activity of CDDPin vitro andin vivo, while the MT level was not increased in cancer (P>0.05), so Lisheng-Se might not only improve the therapeutic index of CDDP, but also did not cause drug-resistance of cancer cells.
Key wordsSe/Pharmacology CDDP/Toxicity Metallothionein
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