Chinese Journal of Cancer Research

, Volume 7, Issue 4, pp 235–238 | Cite as

Nm23 gene expression and its correlation with lymph node metastasis in human lung cancer

  • Lei Wendong
  • Zhang Rugang
  • Yan Shuizhong
  • Wang Xiuqin
  • Mu Juwei
  • Zhang Dawei
  • Wu Min
Basic Investigations

Abstract

Using labelled streptavidin-biotin (LSAB) method, we examined the expression of nucleoside diphosphate (NDP) kinase, the product of metastasis suppressor gene nm23, in human lung cancer. Of 88 patients tested, 48 (54.5%) showed positive staining. The positive staining rate was higher in adenocarcinoma (28/42, 66.7%) than in squamous cell carcinoma (20/46, 43.5%; P<0.05). Higher incidence of positive staining wasalso found in squamous cell carcinomas without hilar or mediastinal lymph node metastasis (16/27, 59.3%) than in those with hilar or mediastinal lymph node involvement (4/19, 21.1%;P<0.05). NDP kinase/nm23 was equally expressed in adeno-carcinoma, irrespective of lymph node status. In both cell types of carcinoma, expression of NDP kinase/nm23 was not correlated with tumor cell differentiation, nor was it correlated with the p-TNM staging. Our results suggest that NDP kinase/nm23 may play different roles in the pathogenesis and metastasis of human pulmonary squamous cell carcinoma and adenocarcinoma. Its expression levels are inversely correlated with lymph node metastasis of squamous cell carcinoma of the lung.

Key words

lung cancer NDP kinase/nm23 metastasis immunohistochemistry 

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Copyright information

© Chinese Journal of Cancer Research 1995

Authors and Affiliations

  • Lei Wendong
    • 1
  • Zhang Rugang
    • 1
  • Yan Shuizhong
    • 2
  • Wang Xiuqin
    • 2
  • Mu Juwei
    • 1
  • Zhang Dawei
    • 1
  • Wu Min
    • 2
  1. 1.Department of Thoracic Surgery, Cancer Institute & HospitalChinese Academy of Medical SciencesBeijing
  2. 2.Department of Cell Biology, Cancer Institute & HospitalChinese Academy of Medical SciencesBeijing

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