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Interleukin-2 (IL-2) production and interleukin-2 receptor expression in patients with aplastic anemia

  • Clinical Observations
  • Published:
Chinese Journal of Cancer Research

Abstract

IL-2 production and IL-2 receptor (Tac antigen) of the peripheral blood mononuclear cells in 30 patients with aplastic anemic (AA) were studied. We found that mononuclear cells from patients produce spontaneously IL-2 in the absence of exogenous lectin stimulation, the proportion of Tac+ cells in mononuclear cells increased. The release of IL-2 and/or Tac antigen expression were elevated in almost every patient with AA. The plasma from patients stimulate mitogen-induced blastogenesis and Tac antigen expression of normal human lymphocytes. Immunological 1 abnormalities of patients with AA possibly might represents secondary response to bone marrow depression.

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References

  1. Mosman T. Rapid colorimetric assay for cellular growth and survival application to proliferation and cytotoxicity assay. J Immunol Methods 1984; 65:55.

    Article  Google Scholar 

  2. Young NS, et al. Lymphocytes and lymphokines in AA pathogenic role and implication for pathogenesis. Blood Cell 1987; 13:87.

    CAS  Google Scholar 

  3. Gascon P, et al. Lymphokine abnormalities in AA implication for the mechanism of action of ALG. Blood 1985; 65(2):407.

    PubMed  CAS  Google Scholar 

  4. Nissen C, et al. The replase of IL-2 and CSA in AA patients oppositic behaviour witr improvement of bone marrow function. Blut 1985; 32:221.

    Google Scholar 

  5. Stefan EG. Receptor-specitic inhibition of bone marrow erythropoietin by recombinant DNA-derived IL-2. Blood 1987; 69(5):1368.

    Google Scholar 

  6. Rosenbery SA, et al. Observations on the systematic administration of autologous lymphokin-activated killer cell and recombinant IL-2 to patients with metastatic cancer. N Engl J Med 1985; 313:1485.

    Article  Google Scholar 

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Authors and Affiliations

  1. The First Affiliated Hospital, Henan Medical University, Zhengzhou

    Lian Tianshun & Zhao Zhiping

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  1. Lian Tianshun
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  2. Zhao Zhiping
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Tianshun, L., Zhiping, Z. Interleukin-2 (IL-2) production and interleukin-2 receptor expression in patients with aplastic anemia. Chinese Journal of Cancer Research 3, 70–73 (1991). https://doi.org/10.1007/BF02672096

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  • DOI: https://doi.org/10.1007/BF02672096

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