Abstract
In a study on erythrocyte polyamine levels in 20 leukemia patients and 18 healthy individuals, following results were obtained. Putrescine(Pu) in erythrocytes was nearly undetectable but in 2 AMoL patients; Spermidine(Spd) level in ALL was higher than the control volue (P<0.05), in AML (M1, M2) and APL the Spd level was in the range of control group (P>0.1), while that in AMoL and AMMoL was considerably lower as compared to control (P<0.001); Spermine (Spm) level in all types of leukemia was increased (P<0.001); Spd/Spm ratio was significantly decreased, showing 1.525 in control group, 0.938 in ALL (P<0.025), 0.779 in AML (M1, M2)P<0.01), 0.319 in APL (P<0.001) and 0.296 in AMoL & AMMoL (P<0.001), and the differences between the Spd/Spm ratio in AMoL and AMMoL and in ALL were noted (P<0.05). These results suggested that determination of erythrocyte polyamines in leukemia patients may be helpful in diagnosis, differential diagnosis and prognosis.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Conellakis ZN, et al. Polyamines and their derivatives as modulators in growth and differentiation. Yale J Biol Med 1989; 62(5):481.
Hospattankar AV, et al. Elevation of serum polyamines in malignant lymphomas and acute myeloid leukemia. Int J Cancer 1980; 25:463.
Smith BJ, et al. Cerebrospinal fluid polyamines in childhood leukemia. Ann Clin Lab Sci 1984; 14:225.
Cooper KD, et al. Polyamine comparatmentali zation in various human disease states. Clin Chim Acto 1978; 82:1.
Niskanen E, et al. The role of polyamine biosynthesis in hematopoietic precursor cell proliferation in mice. Blood 1983; 61:740.
Luk GD, et al. Polyamine biosynthesis is required for the maintenance of peripheral blood cell elements in the rat. Proc Natl Acad Sci USA 1983; 80:5090.
Tadolini B, et al. Intracellular location of polyamines associated to red blood cells. Biochem Biophys Res Commun 1986; 134:1356.
Moulinoux J, et al.In Vitro studies on the entry of polyamines into normal red blood cells, Biochime 1984; 66:385.
Moulinoux J, et al. Red blood cell polyamines in mice bearing the Lewis lung carcinoma (3LL) and in patients with bronchopulmonary cancers. Int J Cancer 1984; 34:277.
Nishioka K, et al. A preliminary study of polyamines in the bone marrow plasma of adult patients with leukemia. Clin Chim Acta 1980; 107:57.
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Jinming, M., Renrong, O. & Ruipeng, P. The relationship between the erythrocyte polyamine levels and the different types of leukemia. Chinese Journal of Cancer Research 3, 66–69 (1991). https://doi.org/10.1007/BF02672095
Issue Date:
DOI: https://doi.org/10.1007/BF02672095