Abstract
Chromosomal fragile sites studies were performed in 40 patients with lymphoma and 30 individuals as healthy controls. The results showed that there was a statistical difference of chromosomal aberration between the two groups; The patients carried 46 fragile sites totally; 21 out of 46 fragile sites in lymphoma corresponded with cancer breakpoints, and 9 fragile sites were located in the bands where concogenes exist. These suggest a certain association between fragile sites, cancer breakpoints and oncogenes and thus indicate a possible important role of fragile sites in the pathogenesis of lymphoma.
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Yuluan, W., Zezhong, T. & Nan, H. Chromosomal fragile sites to lymphoma with observation of 40 patients. Chinese Journal of Cancer Research 3, 46–48 (1991). https://doi.org/10.1007/BF02672090
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DOI: https://doi.org/10.1007/BF02672090