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Sterigmatocystin induced adenocarcinoma of the lung and atypical hyperplasia of glandular stomach in mice

  • Basic Investigations
  • Published:
Chinese Journal of Cancer Research

Abstract

Aspergillus versicolor was isolated from the gastric juice of patients with chronic stomach disease in high-risk area of gastric cancer. Mice fed withAspergillus-inculated corn four developed adenocarcinoma of the lung in 15 of 35 mice (42.9%) and atypical hyperplasia of the glandular stomach in 13 of 35 mice (37.4%). Sterigmatocystin was identified by high performance liquid chromatography (HPLC) and fluorescence spectrophotometry in the extract ofAspergillus-inoculated corn flour. The results suggest that the mycotoxin sterigmatocystin may play a potential role in carcinogenesis in human.

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References

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Authors and Affiliations

  1. Institute of Basic Medicine, Hebei Medical College, Shijazhuang

    Xie Tongxin, Wang Fengrong, Wang Junling & Zhang Zhendong

Authors
  1. Xie Tongxin
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  2. Wang Fengrong
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  3. Wang Junling
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  4. Zhang Zhendong
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Tongxin, X., Fengrong, W., Junling, W. et al. Sterigmatocystin induced adenocarcinoma of the lung and atypical hyperplasia of glandular stomach in mice. Chinese Journal of Cancer Research 3, 31–34 (1991). https://doi.org/10.1007/BF02672086

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  • DOI: https://doi.org/10.1007/BF02672086

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