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The activity of O6-methylguanine DNA methyl-transferase in livers of ducks from Qidong and Qingpu

  • Basic Investigations
  • Published:
Chinese Journal of Cancer Research

Abstract

O6-methylguanine DNA methyltransferase (O6-AT) is an enzyme for the repair of the promutagenic structure, O6-alkylguanine, from alkylated DNA, therefore low activity of O6-AT is involved in the predisposition of tissues to some nitrosamines and the development of cancer. The levels of O6-AT in livers of ducks from Qidong (Qd), a high incidence area of liver cancer, and from Qingpu(Qp), a relatively low incidence area were determined in this study. The results showed that the activity of O6-AT was higher in Qp than in Qd. It suggested that some nitrosamine in Qd might be one of factors responsible for the higher incidence of ducks liver cancer, because these ducks were more sensitive to nitrosamine.

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References

  2. Dolan ME, et al. Use of a dodecadeoxy-nucleotide to study repair of the O4-methylthymine lesion. Mutation Res 1988; 193: 131.

    PubMed  CAS  Google Scholar 

  4. Waldstein EA, et al. Direct assay for O6-methylguanine-acceptor protein in cell extracts. Anal Biochem 1982; 126: 268.

    Article  PubMed  CAS  Google Scholar 

  6. Tapal MD. DNA repair, oncogenes and carcinogenesis. Carcinogenesis 1988; 9: 691.

    Article  Google Scholar 

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Authors and Affiliations

  1. Shanghai Cancer Institute, Shanghai, China

    Wu Yiqian, Qu Yonghua, Yan Qing & Yao Genfu

Authors
  1. Wu Yiqian
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  2. Qu Yonghua
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  3. Yan Qing
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  4. Yao Genfu
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Yiqian, W., Yonghua, Q., Qing, Y. et al. The activity of O6-methylguanine DNA methyl-transferase in livers of ducks from Qidong and Qingpu. Chinese Journal of Cancer Research 3, 1–3 (1991). https://doi.org/10.1007/BF02672080

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  • DOI: https://doi.org/10.1007/BF02672080

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