Medium chain length fatty acid esters and their medical and nutritional applications


Caprylic and capric acid esters and their applications in medical, nutritional and dietetic uses are described. Medium chain triglycer-ides (MCT) as a tool in the control of obesity, control in the choles-terol deposition in the tissues as well as a means of lowering serum cholesterol are cited as unique characteristics of such lipids. MCT as a source of quick energy and high energy is suggested as an alterna-tive to the conventional fats and oils (LCT). Dietetic and nutritional application utilizing the unique characteristics of caprylic and capric acid esters is indicated as alternatives to conventional fats and oils. The mono-diglycerides of caprylic and capric acid as cholesterol dis-solving agents in treating of patients having cholesterol gallstones is described to illustrate the unique solvency properties of such mono esters in medical applications. The possibility of such mono esters of di- and polyhydric alcohols to act as co-solvents for oil and water systems is suggested which can be applied in medical, pharmaceuti-cal and allied fields. Structured lipids with a predominance of capry-lic and capric acid to modify the properties of triglycerides is described for hyperalimentation uses as well as the special nutri-tional and dietetic needs.

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  1. 1.

    Kaunitz, H., A.A. Slanetz, R.E. Johnson, V.K. Babayan and G. Barsky, JAOCS 35:10 (1957).

    Article  Google Scholar 

  2. 2.

    Senior, J.R, “Medium Chain Triglycerides, “ University of Pennsylvania Press, 1967.

  3. 3.

    Babayan, V.K., “Early History and Preparation of MCT,” Soderdruck aus—Supplementa 17 zur Zeitschrift für Ernah- rungswissenschaft, Dr. Dietrich Steinkopff Verlag, Darmstadt, 1974.

    Google Scholar 

  4. 4.

    Babayan, V.K., JAOCS 45:23 (1967).

    Google Scholar 

  5. 5.

    Greenberger, N.J., and T.G. Skillman, N. Eng. J. Med. 280: 1045 (1969).

    CAS  Google Scholar 

  6. 6.

    Kaiser, M.H., Adv. Intern. Med. 17:301 (1971).

    Google Scholar 

  7. 7.

    Schemmel, R., Am. Zool. 16:661 (1976).

    CAS  Google Scholar 

  8. 8.

    Lavau and Hashim, J. Nutr. 108: 613 (1978).

    CAS  Google Scholar 

  9. 9.

    Lavau, Fornari and Hashim, Ibid. 108:621 (1978).

    CAS  Google Scholar 

  10. 10.

    Travis, D., A. Minenna and H. Frier, “Effects of Medium Chain Triglyceride on Energy Metabolism and Body Composition in the Rat,” Federation Proceedings, Abstracts—63rd Annual Meeting, Dallas, Texas, April 1–10, 1979, Nutrition, General IV, 1957, p. 561.

  11. 11.

    Kaunitz, H., Drug Therapy 91 (April 1978).

  12. 12.

    Steward, Wiggers, Jacobsen and Berger, J. Nutr. 108: 561 (1978).

    Google Scholar 

  13. 13.

    Babayan, V.K., JAOCS 51:260 (1974).

    Article  CAS  Google Scholar 

  14. 14.

    Scheig, R., and G. Klatskin, “Hepatic Metabolism of 1-14C Octanoic and l-14C Palmitic Acids,” presented at AOCS Meeting in Philadelphia, PA (1966).

  15. 15.

    Schwabe, A.D., L.R. Benett and L.P. Bowman, J. of Appl. Physiol. 19(2) (March 1964).

  16. 16.

    Tantibhedhyangkul and Hashim, Pediatrics 55:359 (1975).

    CAS  Google Scholar 

  17. 17.

    Tantibhedhyangkul and Hashim, Ibid. 61:537 (1978).

    CAS  Google Scholar 

  18. 18.

    Tantibhedhyangkul and Hashim, Am. J. Clin. Nutr. Abst., p. 674 (1973).

  19. 19.

    Tantighedhyangkul and Hashim, Bull. N.Y. Acad. Med. 47:17 (1971).

    Google Scholar 

  20. 20.

    Clark, B.J., and F.M. House, J. of Human Nutr. 32:111 (1978).

    CAS  Google Scholar 

  21. 21.

    Huttenlocher, P.R., A.J. Wilbourn and J.M. Signore, Neurology 21: 1097 (1971).

    CAS  Google Scholar 

  22. 22.

    Letters to the Editor, J. of Human Nutr. 32 (1978).

  23. 23.

    Sailer, D., and G. Berg, Z. Ernahr. 15(3): 263 (1976).

    Article  CAS  Google Scholar 

  24. 24.

    Captex 810 Series Bulletin, Capital City Products, Columbus, Ohio.

  25. 25.

    U.S. Patent 3,331,742 (July 1967).

  26. 26.

    Pasquale, D., D. Jaconia, P. Eisman and L. Lachman, Bull, of the Parenter. Drug Assoc. 18(3) (1964).

  27. 27.

    Capmul 8210 (MCM) Pharmaceutical Grade Bulletin, Capital City Products, Columbus, Ohio.

  28. 28.

    Thistle, J.L., G.L. Carlson, A.F. Hofmann and V.K. Babayan, Gastroenterology (May 1977).

  29. 29.

    Mack, E.A., et al., Surg. Forum 29 (1978).

  30. 30.

    Babayan, V.K., Proceedings in Publication, Conference on MCT, Montreal, Quebec, Canada (October 1979).

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Babayan, V.K. Medium chain length fatty acid esters and their medical and nutritional applications. J Am Oil Chem Soc 58, 49A–51A (1981).

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  • Capric Acid
  • Medium Chain Triglyceride
  • Cholesterol Gallstone
  • Polyhydric Alcohol
  • Alkali Refining