Abstract
Almost all reported cases of large cell neuroendocrine carcinoma (LCNEC) of the lung are solid-type tumors. We encountered a rare case of LCNEC displaying a cystic shape. An abnormal cystic shadow was revealed on chest computed tomography in a 71-year-old man who underwent total gastrectomy due to gastric cancer 5 years earlier. The cystic lesion enlarged from 7 mm to 16 mm over 7 months, so surgery was performed for definitive diagnosis and therapy. Microscopy revealed rosette patterns, a high mitotic rate and a large area of necrosis. Neuroendocrine differentiation was confirmed on immunohistochemical examinations using chromogranin, synaptophysin and NCAM (CD56). Given these findings, LCNEC was diagnosed. This is the first report of LCNEC with a cystic shape. This case challenges preconceptions regarding the radiographic appearance of LCNEC. (Jpn J Thorac Cardiovasc Surg 2006; 54:174-177)
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References
Travis WD, Linnoila RI, Tsokos MG, Hitchcoch CL, Cutler GB Jr, Nieman L, et al. Neuroendocrine tumors of the lung with proposed criteria for large-cell neuroendocrine carcinoma. An ultrastructural, immunohistochemical, and flow cytometric study of 35 cases. Am J Surg Pathol 1991; 15:529–53.
World Health Organization. Histological Typing of Lung and Pleural Tumours. 3rd ed. Berlin: Springer, 1999.
Jiang SX, Kameya T, Shoji M, Dobashi Y, Shinada J, Yoshimura H. Large cell neuroendocrine carcinoma of the lung: A histologic and immunohistochemical study of 22 cases. Am J Surg Pathol 1998; 22:526–37.
Oshiro Y, Kusumoto M, Matsuno Y, Asamura H, Tsuchiya R, Terasaki H, et al. CT findings of surgically resected large cell neuroendocrine carcinoma of the lung in 38 patients. AJR Am J Roentgenol 2004; 182:87–91.
Hamanaka N, Yamada K, Suzuki R, Saito H, Oshita F, Noda K, et al. Large cell neuroendocrine carcinoma of the lung: Clinical features, computed tomography evaluation and correlation with pathological features (Eng abstr). Rinsho Hoshasen 2004; 49:141–50.
Jung KJ, Lee KS, Han J, Kwon OJ, Kim J, Shim YM, et al. Large cell neuroendocrine carcinoma of the lung: Clinical, CT, and pathologic findings in 11 patients. J Thorac Imaging 2001; 16:156–62.
Shin AR, Shin BK, Choi JA, Oh YW, Kim HK, Kang EY. Large cell neuroendocrine carcinoma of the lung: Radiologic and pathologic findings. J Comput Assist Tomogr 2000; 24:567–73.
Takei H, Asamura H, Maeshima A, Suzuki K, Kondo H, Niki T, et al. Large cell neuroendocrine carcinoma of the lung: A clinicopathologic study of eighty-seven cases. J Thorac Cardiovasc Surg 2002; 124:285–92.
Travis WD, Rush W, Flieder DB, Falk R, Fleming MV, Gal AA, et al. Survival analysis of 200 pulmonary neuroendocrine tumors with clarification of criteria for atypical carcinoid and its separation from typical carcinoid. Am J Surg Pathol 1998; 22:934–44.
Doddoli C, Barlesi F, Chetaille B, Garbe L, Thomas P, Giudicelli R, et al. Large cell neuroendocrine carcinoma of the lung: An aggressive disease potentially treatable with surgery. Ann Thorac Surg 2004; 77:1168–72.
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Tanaka, K., Tsuboi, M. & Kato, H. Large cell neuroendocrine carcinoma of the lung with a cystic appearance on computed tomography. Jpn J Thorac Caridovasc Surg 54, 174–177 (2006). https://doi.org/10.1007/BF02662475
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DOI: https://doi.org/10.1007/BF02662475