Abstract
We report a rare case of multiple endocrine neoplasia (MEN) type 1 with thymoma. A 57-year-old woman with a chronic duodenal ulcer and hypoglycemia had been seen at a nearby clinic. Abdominal echogram revealed two nodules in the pancreas and she was referred to our hospital for evaluation. Her diagnosis was MEN type 1, gastrinoma and hyperparathyroidism with anterior mediastinal tumor. There were high calcium levels in the blood and urine. Gastrin was quite high. A chest X-ray revealed a retrosternal tumor. Computed tomography revealed an anterior mediastinal tumor without sign of invasion to the surrounding organs, and two small masses in the pancreas. Cervical echogram revealed a few masses in both sides behind the thyroid. From these findings, her preoperative diagnosis was MEN type 1 with thymic carcinoid or thymoma. We performed thymectomy and parathyroidectomy concomitantly. The mediastinal tumor was diagnosed as invasive thymoma. (Jpn J Thorac Cardiovasc Surg 2006; 54:171-173)
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References
Elaraj DM, Skarulis MC, Libutti SK, Norton JA, Bartlett DL, Pingpank JF, et al. Results of initial operation for hyperparathyroidism in patients with multiple endocrine neoplasia type 1. Surgery 2003; 134: 858–65.
Kondo R, Yamanda T, Makiuchi A, Numanami H, Takasuna K, Machida E, et al. A case of thymic carcinoid with multiple endocrine neoplasm (MEN)-type I (Eng abstr). Kyobu Geka 1999; 52: 875–8.
Teh BT, Zedenius J, Kytola S, Skogseid B, Trotter J, Choplin H, et al. Thymic carcinoids in multiple endocrine neoplasia type 1. Ann Surg 1998; 228: 99–105.
Yoshimoto K, Saito S. Clinical characteristics in multiple endocrine neoplasia type 1 in Japan: A review of 106 patients (Eng abstr). Nippon Naibunpi Gakkai Zasshi 1991; 67: 764–74.
Gibril F, Schumann M, Pace A, Jensen RT. Multiple endocrine neoplasia type 1 and Zollinger-Ellison syndrome: A prospective study of 107 cases and comparison with 1009 cases from the literature. Medicine (Baltimore) 2004; 83: 43–83.
Chanson P, Cadiot G, Murat A. Management of patients and subjects at risk for multiple endocrine neoplasia type 1: MEN 1. GENEM 1. Groupe d’Etude des Neoplasies Endocriniennes Multiples de type 1. Horm Res 1997; 47: 211–20.
Yoneda S, Matsuzoe D, Kawahara K, Shirakusa T. Surgical therapy for patients with thymoma or thymic carcinoma; based on WHO classification (Eng abstr). Kyobu Geka 2002; 55: 926–30.
Shimosato Y, Mukai K. Tumors of the thymus and related lesions. In: Tumors of the Mediastinum. Washington, D.C.: AFIP, 1995: 40–120.
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Kojima, Y., Ito, H., Hasegawa, S. et al. Resected invasive thymoma with multiple endocrine neoplasia type 1. Jpn J Thorac Caridovasc Surg 54, 171–173 (2006). https://doi.org/10.1007/BF02662474
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DOI: https://doi.org/10.1007/BF02662474