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Prostaglandin el attenuates impairment of cellular immunity after cardiopulmonary bypass

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Objective

It is well documented that cardiopulmonary bypass (CPB) severely impairs cellular immunity. The objective of this study was to investigate the effect of prostaglandin El (PGE1) on cellular immunity after CPB.Methods: Patients who underwent elective cardiac surgery were randomly divided into the PGE1 group (n=12) and the control group (n=12). In the PGE1 group, PGE1 was administered at 20 ng/kg/min from just after the induction of anesthesia to the end of surgery. Peripheral blood mononuclear cells (PBMCs) were taken before anesthesia and on postoperative days 1,3 and 7 (POD 1, POD 3 and POD 7). Proliferation responses of T cells to phytohemagglutinin (PHA) and pure protein derivative (PPD) antigen were measured as indicators of cellular immunity.Results: PGE1 significantly attenuated the impairment of both PHA and PPD response after cardiac surgery on POD 1 (PHA response, 30 ± 21% vs. 53±32%, control vs. PGE, p=0.048; PPD response, 18±21% vs. 39±27%, control vs. PGE, p=0.046). The reduced glutathione content of PBMCs in the control group was significantly decreased on POD 1.Conclusion: PGE1 attenuated the impairment of cellular immunity after cardiac surgery with CPB by reducing oxidative stress on PBMCs. (Jpn J Thorac Cardiovasc Surg 2006; 54:149-154)

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Authors and Affiliations

  1. Department of Cardiovascular Surgery, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan

    Tetsuro Sano MD, Munetaka Masuda MD, Shigeki Morita MD & Hisataka Yasui MD

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  1. Tetsuro Sano MD
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  2. Munetaka Masuda MD
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  3. Shigeki Morita MD
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  4. Hisataka Yasui MD
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Sano, T., Masuda, M., Morita, S. et al. Prostaglandin el attenuates impairment of cellular immunity after cardiopulmonary bypass. Jpn J Thorac Caridovasc Surg 54, 149–154 (2006). https://doi.org/10.1007/BF02662469

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  • DOI: https://doi.org/10.1007/BF02662469

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