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Familial adenomatous polyposis and duodenal lymphoma

report of a case

  • Published:
Diseases of the Colon & Rectum

Abstract

The occurrence of duodenal polyposis is well recognized in familial adenomatous polyposis. Lymphoid hyperplasia in association with familial adenomatous polyposis usually occurs in the terminal ileum, but it can occur in the duodenum and may be endoscopically difficult to distinguish from an adenoma. A case report is presented in which a 54-yearold male with familial adenomatous polyposis, who 20 years earlier had a subtotal colectomy and ileorectal anastomosis, presented with a large rectal villous tumor and was found to have a duodenal extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue. The role of lymphoid hyperplasia in the development of mucosa-associated lymphoid tissue lymphoma is discussed, as well as the issue of mucosa-associated lymphoid tissue lymphoma in familial adenomatous polyposis. In cases in which biopsies of polypoid lesions in patients with familial adenomatous polyposis show dense lymphoid aggregates, flow cytometry may assist in the diagnosis.

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References

  1. Spigelman AD, Phillips RK. The upper gastrointestinal tract. In: Phillips RK, Spigelman AD, Thomson JP, eds. Familial adenomatous polyposis and other polyposis syndromes. London: Edward Arnold, 1994:106–27.

    Google Scholar 

  2. Jarvinen H, Nyberg M, Peltokallio P. Upper gastrointestinal tract polyps in familial adenomatosis coli. Gut 1983;24:333–9.

    PubMed  CAS  Google Scholar 

  3. Brett MC, Hershman MJ, Glazer G. Other manifestations of familial adenomatous polyposis. In: Phillips RK, Spigelman AD, Thomson JP, eds. Familial adenomatous polyposis and other polyposis syndromes. London: Edward Arnold, 1994:143–58.

    Google Scholar 

  4. Thompson-Fawcett MW, Marcus VA, Redston M, Cohen Z, McLeod RS. Adenomatous polyps develop commonly in the ileal pouch of patients with familial adenomatous polyposis. Dis Colon Rectum 2001;44:347–53.

    Article  PubMed  CAS  Google Scholar 

  5. Fenoglio-Preiser C, Noffsinger A, Stemmermann G, Lantz P, Listrom M, Rilke F. Gastrointestinal pathology: an atlas and text. 2nd ed. New York: Lippincott-Raven, 1999:1129–67.

    Google Scholar 

  6. Anonymous. Abstracts from the Fourth Biannual Meeting of the Leeds Castle Polyposis Group. Int J Colorectal Dis 1991,6:224-36.

  7. Nakajima H, Iwama T, Lamiyama R, Mishima Y. A case of adenomatosis coli complicated with malignant lymphoma of the spleen. Jpn J Surg 1990;20:351–5.

    Article  PubMed  CAS  Google Scholar 

  8. Parsonnet J, Hansen S, Rodriguez L,et al. Helicobacter pylori infection and gastric lymphoma. N Engl J Med 1994;330:1267–71.

    Article  PubMed  CAS  Google Scholar 

  9. Wotherspoon AC, Ortiz-Hidalgo C, Falzon MR, Isaacson PG. Helicobacter pylori-associated gastritis and primary B-cell lymphoma. Lancet 1991;338:1175–6.

    Article  PubMed  CAS  Google Scholar 

  10. Matsumoto T, Lida M, Shimizu M. Regression of mucosa-associated lymphoid-tissue lymphoma of rectum after eradication of Helicobacter pylori. Lancet 1997;350:115–6.

    Article  PubMed  CAS  Google Scholar 

  11. Toshima M, Aikawa K, Soga K,et al. Primary duodenal MALT lymphoma. Intern Med 1999;38:957–6l.

    PubMed  CAS  Google Scholar 

  12. Vanhoutte J. Polypoid lymphoid hyperplasia of the terminal ileum in patients with familial polyposis coli and with Gardner’s syndrome. AJR Am J Roentgenol 1970; 110:340–2.

    CAS  Google Scholar 

  13. Gruenberg J, Mackman S. Multiple lymphoid polyps in familial polyposis. Ann Surg 1972;175:552–4.

    Article  PubMed  CAS  Google Scholar 

  14. Tytgat G, Gopinath N. Recurrent polyps in the ileo-anal pouch or rectum in familial adenomatous polyposis. Eur J Cancer 1995;31A:1154–9.

    Article  PubMed  CAS  Google Scholar 

  15. Castellano G, Moreno D, Galvao O,et al. Malignant lymphoma of jejunum with common variable hypogammaglobulinemia and diffuse nodular hyperplasia of the small intestine. A case study and literature review. J Clin Gastroenterol 1992; 15:128–35.

    Article  PubMed  CAS  Google Scholar 

  16. Gonzalez-Vitale J, Gomez L, Goldblum R, Goldman A, Patterson M. Immunoblastic lymphoma of small intestine complicating late-onset immunodeficiency. Cancer 1982;49:445–9.

    Article  PubMed  CAS  Google Scholar 

  17. Lamers C, Wagener T, Assmann K, van Tongeren J. Jejunal lymphoma in a patient with primary adult-onset hypogammaglobulinemia and nodular lymphoid hyperplasia of the small intestine. Dig Dis Sci 1980;25:553–7.

    Article  PubMed  CAS  Google Scholar 

  18. Pawade J, Soon Lee C, Ellis D, Vellar I, Rode J. Primary lymphoma of the ampulla of Vater. Cancer 1994; 73:2083–6.

    Article  PubMed  CAS  Google Scholar 

  19. Martin M, Hammann A, Martin F. Gut-associated lymphoid tissue and 1,2-dimethylhydrazine intestinal tumors in the rat: an histological and immunoenzymatic study. Int J Cancer 1986;38:75–80.

    Article  PubMed  CAS  Google Scholar 

  20. Hillon P, Martin M, Piard F, Jacquot J. Relation between adenomas and colorectal-associated lymphoid tissue in familial polyposis coli [letter]. Dig Dis Sci 1990;35:1307–8.

    Article  PubMed  CAS  Google Scholar 

  21. Braylan RC, Benson NA. Flow cytometric analysis of lymphomas. Arch Pathol Lab Med 1989;113:627–33.

    PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. Colorectal Unit, Christchurch School of Medicine and Hospital, Christchurch, New Zealand

    F. A. Frizelle M.B.Ch.B., M.Med.Sci., F.R.A.C.S.

  2. Department of Surgery and Pathology, Christchurch School of Medicine and Hospital, Christchurch, New Zealand

    C. T. Hemmings B.H.B., M.B.Ch.B. & M. R. Whitehead M.B.Ch.B., F.R.C.P.A.

  3. Faculty of Health, The University of Newcastle, Newcastle, Australia

    A. D. Spigelman M.B.B.S., F.R.A.C.S

Authors
  1. F. A. Frizelle M.B.Ch.B., M.Med.Sci., F.R.A.C.S.
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  2. C. T. Hemmings B.H.B., M.B.Ch.B.
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  3. M. R. Whitehead M.B.Ch.B., F.R.C.P.A.
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  4. A. D. Spigelman M.B.B.S., F.R.A.C.S
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Frizelle, F.A., Hemmings, C.T., Whitehead, M.R. et al. Familial adenomatous polyposis and duodenal lymphoma. Dis Colon Rectum 46, 1698–1701 (2003). https://doi.org/10.1007/BF02660778

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  • DOI: https://doi.org/10.1007/BF02660778

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