References
Akira, S., Okazaki, K., and Sakano, H. Two pairs of recombination signals are sufficient to cause immunoglobulin V-(D)-J joining.Science 238: 1134–1138, 1987
Connor, A. M., Fanning, L. J., Celler, J. W., Hivks, L. K., Ramsden, D. A., and Wu, G. E. Mouse VH7183 recombination signal sequences mediate recombination more frequently than those of VHJ558.J Immunol 155: 5268–5272, 1995
Gauss, H. and Lieber, M. The basis for the mechanistic bias for deletional over inversional V(D)J recombination.Genes & Dev 6: 1553–1561, 1992
Hesse, J. E., Lieber, M. R., Gellert, M., and Mizuuchi, K. Extrachromosomal DNA substrates in pre-B cells undergo inversion or deletion at immunoglobulin V-(D)-J joining signals.Cell 49: 775–783, 1987
Hesse, J. E., Lieber, M. R., Mizuuchi, K., and Gellert, M. V(D)J recombination: a functional definition of the joining signals.Genes & Dev 3: 1053–1061, 1989
Hsieh, C.-L. and Lieber, M. R. CpG methylated minichromosomes become inaccessible for V(D)J recombination after undergoing replication.EMBO J 11: 315–325, 1992
Lewis, S. The mechanisms of V(D)J joining: lessons from molecular, immunological and comparative analyses.Adv Immunol 56: 27–150, 1994
Lewis, S., Rosenberg, N., Alt, F., and Baltimore, D. Continuing kappa gene rearrangement in a cell line transformed by the Abelson murine leukemia virus.Cell 30: 807–816, 1982
Lieber, M. The mechanism of V(D)J recombination: a balance of diversity, specificity, and stability.Cell 70: 873–876, 1992
Lieber, M. R., Hesse, J. E., Mizuuchi, K., and Gellert, M. Lymphoid V(D)J recombination: Nucleotide insertion at signal joints as well as coding joints.Proc Natl Acad Sci 85: 8588–8592, 1988
Ramsden, D. A. and Wu, G. E. Mouse k light-chain recombination signal sequences mediate recombination more frequently than those of λ light chain.Proc Natl Acad Sci 88: 10721 -10725, 1991
Ramsden, D. A. and Wu, G. E. The virgin B cell lambda: kappa ratio.Res Immunol 143: 811–817, 1992
Ramsden, D. A., Baetz, K., and Wu, G. E. Conservation and functional significance of the V(D)J recombination signal sequences.Nucleic Acids Res 22: 1785–1796, 1994
Sakano, H., Maki, R., Kurosawa, Y., Roeder, W., and Tonegawa, S. Two types of somatic recombination are necessary for the generation of complete immunoglobulin heavy-chain genes.Nature 286: 676–683, 1980
Wei, Z. and Lieber, M. Lymphoid V(D)J recombination: functional analysis of the spacer sequence within the recombination signal.J Biol Chem 268: 3180–3183, 1993
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Fanning, L., Connor, A., Baetz, K. et al. Mouse RSS spacer sequences affect the rate ofV(D)J recombInatIon. Immunogenetics 44, 146–150 (1996). https://doi.org/10.1007/BF02660064
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DOI: https://doi.org/10.1007/BF02660064